An atlas of genetic correlations across human diseases and traits
Identifying genetic correlations between complex traits and diseases can provide useful
etiological insights and help prioritize likely causal relationships. The major challenges …
etiological insights and help prioritize likely causal relationships. The major challenges …
High-definition likelihood inference of genetic correlations across human complex traits
Z Ning, Y Pawitan, X Shen - Nature genetics, 2020 - nature.com
Genetic correlation is a central parameter for understanding shared genetic architecture
between complex traits. By using summary statistics from genome-wide association studies …
between complex traits. By using summary statistics from genome-wide association studies …
Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
Accumulating evidence from genome wide association studies (GWAS) suggests an
abundance of shared genetic influences among complex human traits and disorders, such …
abundance of shared genetic influences among complex human traits and disorders, such …
Detection and interpretation of shared genetic influences on 42 human traits
We performed a scan for genetic variants associated with multiple phenotypes by comparing
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
Genetic correlations of polygenic disease traits: from theory to practice
W Van Rheenen, WJ Peyrot, AJ Schork… - Nature Reviews …, 2019 - nature.com
The genetic correlation describes the genetic relationship between two traits and can
contribute to a better understanding of the shared biological pathways and/or the causality …
contribute to a better understanding of the shared biological pathways and/or the causality …
Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits
Genetic correlations estimated from genome-wide association studies (GWASs) reveal
pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural …
pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural …
Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits
We developed a likelihood-based approach for analyzing summary-level statistics and
external linkage disequilibrium information to estimate effect-size distributions of common …
external linkage disequilibrium information to estimate effect-size distributions of common …
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
We present an approximate conditional and joint association analysis that can use summary-
level statistics from a meta-analysis of genome-wide association studies (GWAS) and …
level statistics from a meta-analysis of genome-wide association studies (GWAS) and …
[PDF][PDF] Local genetic correlation gives insights into the shared genetic architecture of complex traits
Although genetic correlations between complex traits provide valuable insights into
epidemiological and etiological studies, a precise quantification of which genomic regions …
epidemiological and etiological studies, a precise quantification of which genomic regions …
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
Genome-wide association studies (GWAS) have identified thousands of genetic variants
associated with human complex traits. However, the genes or functional DNA elements …
associated with human complex traits. However, the genes or functional DNA elements …