Cutaneous phototype is considered mainly related to cutaneous pigmentation and to the
eumelanin/pheomelanin ratio, which is mostly genetically determined by the melanocortin 1 …

Cutaneous pigmentation is the major photoprotective mechanism against the carcinogenic
and aging effects of UV. Epidermal melanocytes synthesize the pigment melanin, in the form …

The significance of human cutaneous pigmentation lies in its protective role against sun‐
induced DNA damage and photocarcinogenesis. Fair skin and red hair are characterized by …

Skin pigmentation is due to the accumulation of two types of melanin granules in the
keratinocytes. Besides being the most potent blocker of ultraviolet radiation, the role of …

Cutaneous pigmentation is determined by the amounts of eumelanin and pheomelanin
synthesized by epidermal melanocytes and is known to protect against sun-induced DNA …

The constitutive color of our skin plays a dramatic role in our photoprotection from solar
ultraviolet radiation (UVR) that reaches the Earth and in minimizing DNA damage that gives …

Abstract Melanocortin‐1 Receptor (MC1R), when stimulated by alpha‐melanocyte‐
stimulating hormone (α‐MSH), is a driver of eumelanogenesis. Brown/black eumelanin is an …

Beginning in the last decade of the twentieth century, the fields of pigment cell research and
melanoma have witnessed major breakthroughs in the understanding of the role of …

The melanocortin 1 receptor gene is a main determinant of human pigmentation, and a
melanoma susceptibility gene, because its variants that are strongly associated with red hair …

The cloning of the melanocortin-1 receptor (MC1R) gene from human melanocytes and the
demonstration that these cells respond to the melanocortins α-melanocyte stimulating …