Background Caloric restriction (CR) can increase longevity in rodents and improve memory
function in humans. α-Lipoic acid (LA) has been shown to improve memory function in rats …

Calorie restriction (CR) enhances longevity and mitigates aging phenotypes in numerous
species. Physiological responses to CR are cell-type specific and variable throughout the …

Calorie restriction (CR) increases lifespan and improves brain health in mice. Ad libitum low-
protein, high-carbohydrate (LPHC) diets also extend lifespan, but it is not known whether …

Background The structural and functional complexity of the mammalian central nervous
system (CNS) is organized and modified by complicated molecular signaling processes that …

Background Brain aging is a complex process that depends on the precise regulation of
multiple brain regions; however, the underlying molecular mechanisms behind this process …

Caloric restriction (CR) and chemical agents, such as resveratrol and rapamycin that
partially mimic the CR effect, can delay morbidity and mortality across a broad range of …

Dietary restriction (DR) during adulthood can greatly extend lifespan and improve metabolic
health in diverse species. However, whether DR in mammals is still effective when applied …

Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However,
there are a number of emerging experimental variables that alter CR responses. We …

Fasting may be exploited as a possible strategy for prevention and treatment of several
diseases such as diabetes, obesity, and aging. On the other hand, high-fat diet (HFD) …

Caloric restriction (CR), the consumption of fewer calories while avoiding malnutrition,
decelerates the rate of aging and the development of age-related diseases. CR has been …