Xanthine oxidase (XO), a key enzyme in purine catabolism, is widely distributed in human
tissues. It can catalyze xanthine to generate uric acid and cause hyperuricemia and gout …

Xanthine oxidase (XO) catalyses hypoxanthine and xanthine to uric acid in human
metabolism. Overproduction of uric acid will lead to hyperuricemia and finally cause gout …

The xanthine oxidase (XO) inhibitory activity is an important way to evaluate the anti-
hyperuricemia effect of natural products. In the present work, the XO inhibitory effect of …

Suppression of xanthine oxidase (XO) may contribute to control hyperuricemia and gout. In
this study, baicalein and baicalin, two dietary flavones, were found to inhibit the formation of …

Hyperuricemia (HUA) is a metabolic disease caused by excessive uric acid in patients.
Flavonoids have attracted extensive attention due to their safety, effectiveness, and little side …

Quercetin, one of the most abundant flavonoid in the daily diet, was found to reversibly
inhibit the generation of uric acid and superoxide radicals (O 2−) catalyzed by xanthine …

Chrysin, a bioactive flavonoid, was investigated for its potential to inhibit the activity of
xanthine oxidase (XO), a key enzyme catalyzing xanthine to uric acid and finally causing …

Polyphenols have been used as natural medicaments for the management of hyperuricemia
for a long history. They have been attracted many interests because of the little side effects …

Xanthine oxidase (XOD) inhibitory activities of five dietary flavonoids pinobanksin, galangin,
pinocembrin, pinocembrin-7-O-β-d-glucopyranoside and glabranin were evaluated. Enzyme …

In this study, some flavonoids were screened as potent xanthine oxidase (XO) inhibitors in
vitro. Flavonoid 9 was demonstrated to exhibit the inhibitory activity through a ping-pong …