Intestinal delivery of heterologous peptides with lactobacilli

L Zhang - 2015 - ideals.illinois.edu
Oral administration of autoantigen is a promising method to induce oral tolerance in
autoimmune diseases, such as multiple sclerosis. Multiple sclerosis (MS) is a complex …

Orally administered Lactobacillus strains used for tolerance induction may affect Th1-Th2 balance

CBM Maassen, J van Holten, R Leer, JD Laman… - Immunology …, 1997 - infona.pl
Introduction: Oral administration of autoantigens is a safe and convenient way to induce
peripheral T cell tolerance in autoimmune diseases like multiple sclerosis. To increase the …

Reduced experimental autoimmune encephalomyelitis after intranasal and oral administration of recombinant lactobacilli expressing myelin antigens

CBM Maassen, JD Laman, C van Holten-Neelen… - Vaccine, 2003 - Elsevier
Oral administration of autoantigens is a safe and convenient way to induce peripheral T-cell
tolerance in autoimmune diseases like multiple sclerosis (MS). To increase the efficacy of …

Lactobacillus Mediated Delivery of Therapeutic Peptides in the Gastrointestinal Tract

Y Lin - 2017 - search.proquest.com
Lactobacilli are normal residents of the human gastrointestinal (GI) tract. Many species
belonging to the genera Lactobacillus with health beneficial properties have been …

[图书][B] Lactobacilli as antigen delivery system for mucosal tolerance induction in autoimmune disease

C Maassen - 1999 - repub.eur.nl
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(eNS) that affects eNS myelin which isolates nerve axons and allows saltatory pulse …

A new lactobacilli in vivo expression system for the production and delivery of heterologous proteins at mucosal surfaces

T Allain, NM Mansour, MMA Bahr… - FEMS Microbiology …, 2016 - academic.oup.com
Food-grade lactic acid bacteria, such as lactobacilli, represent good candidates for the
development of mucosal vectors. Indeed, they are generally recognized as safe …

Construction of human granulocyte-macrophage colony-stimulating factor expression system using Lactococcus lactis MG1363.

HYF Hong YiFan, HMS Ham MinSeok… - 2015 - cabidigitallibrary.org
Lactic acid bacteria (LAB) have been used in a wide variety of industrial fermentation
processes. Generally, LAB have regarded as safe status, making them potentially useful …

[PDF][PDF] Mouse-strain specific immunogenicity of Lactococcus lactis: implications for the use of L. lactis antigen delivery system for oral tolerance induction

V Snoeck, IL Huibregtse, N Ongenae… - Antigen-specific oral … - dare.uva.nl
Abstract Background & Aims: The major goal of immunotherapy for autoimmune and allergic
diseases is to obtain antigen-specific immune suppression mediated by regulatory T cells …

Instruments for oral disease-intervention strategies: recombinant Lactobacillus casei expressing tetanus toxin fragment C for vaccination or myelin proteins for oral …

CBM Maassen, JD Laman, MJH den Bak-Glashouwer… - Vaccine, 1999 - Elsevier
Lactobacillus strains possess properties that make them attractive candidates as vehicles for
oral administration of therapeutics. In this report we describe the construction and analysis of …

Probiotic bacteria as a functional delivery vehicle for the development of live Oral vaccines

M Dadar, Y Shahali, N Mojgani - … metabolites: Role in animal and human …, 2021 - Springer
Probiotics improve the immune system and help to fight with different infection. The LAB
ability in eliciting the immune response against foreign antigens has led to their use as …