Drug for cholestasis therapy is extremely limited. Ur-sodeoxycholic acid is currently the only
FDA approved drug to treat primary biliary cirrhosis, whereas its efficacy is limited to early …

胆汁酸是胆固醇代谢的终末产物, 包括初级胆汁酸和次级胆汁酸两大类, 其可通过作用于胆汁酸
核受体和膜受体影响物质吸收和调节免疫应答, 糖, 脂和能量代谢, 肠道菌群稳态 …

Nuclear receptors are key regulators of various processes including reproduction,
development, and metabolism of xeno-and endobiotics such as bile acids and drugs …

胆汁酸是胆固醇代谢的主要终产物, 也是肝和小肠对食物中的脂类进行分解,
吸收与转运的重要成分. 体内多种核受体参与胆汁酸的代谢调节, 如法呢醇受体, 孕烷X 受体 …

Nuclear Receptors as Drug Targets in Cholestatic Liver Diseases - Clinics in Liver Disease
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Cholestatic liver disease is caused by the obstruction of bile synthesis, transport, and
excretion in or outside the liver by a variety of reasons. Long-term persistent cholestasis in …

胆汁淤积(cholestasis) 是临床常见的一组征候群, 产生的原因十分复杂. 尽管对胆汁淤积的研究
已进入到分子学水平, 发病机制日益明确, 诊断方法及治疗药物不断更新, 但对肝内胆汁淤积的 …

Bile acids (BAs) are traditionally considered as “physiological detergents” for emulsifying
hydrophobic lipids and vitamins due to their amphipathic nature. But accumulating clinical …