Fracture healing: mechanisms and interventions

TA Einhorn, LC Gerstenfeld - Nature Reviews Rheumatology, 2015 - nature.com
Fractures are the most common large-organ, traumatic injuries to humans. The repair of
bone fractures is a postnatal regenerative process that recapitulates many of the ontological …

Trauma-induced inflammation and fracture healing

HC Pape, R Marcucio, C Humphrey… - … of orthopaedic trauma, 2010 - journals.lww.com
Fracture healing is an extremely complex interaction of cells, biologic pathways, and
molecules. Certainly, the inflammatory response is one of the initiating factors for bone …

Bone injury and fracture healing biology

A Oryan, S Monazzah, A Bigham-Sadegh - Biomedical and environmental …, 2015 - Elsevier
Bones are organs of the skeletal system, providing shape, mechanical support, and
protection to the body and facilitating the movement. In addition, bones contribute to the …

Overview of the fracture healing cascade

AM Phillips - Injury, 2005 - Elsevier
Fracture healing is a dynamic process being governed by a variety of cellular elements and
stimulating agents. Our knowledge in understanding the molecular and cellular processes …

The biology of fracture healing

R Marsell, TA Einhorn - Injury, 2011 - Elsevier
The biology of fracture healing is a complex biological process that follows specific
regenerative patterns and involves changes in the expression of several thousand genes …

Inflammation, fracture and bone repair

F Loi, LA Córdova, J Pajarinen, T Lin, Z Yao… - Bone, 2016 - Elsevier
The reconstitution of lost bone is a subject that is germane to many orthopedic conditions
including fractures and non-unions, infection, inflammatory arthritis, osteoporosis …

The control of fracture healing and its therapeutic targeting: improving upon nature

DE Komatsu, SJ Warden - Journal of cellular biochemistry, 2010 - Wiley Online Library
Fracture repair is a complex process involving timed cellular recruitment, gene expression,
and synthesis of compounds that regenerate native tissue to restore the mechanical …

Current concepts of molecular aspects of bone healing

R Dimitriou, E Tsiridis, PV Giannoudis - Injury, 2005 - Elsevier
Fracture healing is a complex physiological process. It involves the coordinated participation
of haematopoietic and immune cells within the bone marrow in conjunction with vascular …

Cellular biology of fracture healing

CS Bahney, RL Zondervan, P Allison… - Journal of …, 2019 - Wiley Online Library
The biology of bone healing is a rapidly developing science. Advances in transgenic and
gene‐targeted mice have enabled tissue and cell‐specific investigations of skeletal …

Recent developments in the biology of fracture repair

FNK Kwong, MB Harris - … -Journal of the American Academy of …, 2008 - journals.lww.com
Fracture repair is dependent on local and systemic molecular and cellular processes. During
fracture repair, mesenchymal stem cells are systemically recruited to the fracture site, and …