Selenoprotein N (SEPN1) is a broadly expressed resident protein of the endoplasmic
reticulum (ER) whose loss-of-function inexplicably leads to human muscle disease. We …

Selenoprotein N (SEPN1) is a type II glycoprotein of the endoplasmic reticulum (ER) that
senses calcium levels to tune the activity of the sarcoplasmic reticulum calcium pump …

Mutations in the human SEPN1 gene, encoding selenoprotein N (SepN), cause SEPN1-
related myopathy (SEPN1-RM) characterized by muscle weakness, spinal rigidity, and …

Selenoprotein N (SELENON) is an endoplasmic reticulum (ER) protein whose loss of
function leads to human SELENON-related myopathies. SelenoN knockout (KO) mouse limb …

Selenium is an essential trace element and selenoprotein N (SelN) was the first selenium-
containing protein shown to be directly involved in human inherited diseases. Mutations in …

Selenoprotein N (SEPN1) is a protein of the endoplasmic reticulum (ER) whose inherited
defects originate SEPN1-related myopathy (SEPN1-RM). Here, we identify an interaction …

Selenoprotein N (SELENON) is an endoplasmic reticulum (ER) protein whose loss of
function leads to a congenital myopathy associated with insulin resistance (SEPN1-related …

Objective Mutations of the selenoprotein N gene (SEPN1) cause SEPN1‐related myopathy
(SEPN1‐RM), a novel early‐onset muscle disorder formerly divided into four different …

Healthy cells continually produce low levels of reactive oxygen species (ROS), which are
buffered by multiple antioxidant systems. Imbalance between ROS production and …

The crucial role of the trace element selenium in livestock and human health, in particular in
striated muscle function, has been well established but the underlying molecular …