The gastrointestinal tract, due to its role as a digestive organ and as a barrier between the
exterior and interior milieus, is critically impacted by dietary, environmental, and …

As a barrier epithelium, the intestinal epithelium has to coordinate physiological functions
like digestion and nutrient resorption with the control of commensal bacteria and the …

Aging is characterized by a growing risk of disease and death, yet the underlying
pathophysiology is poorly understood. Indeed, little is known about how the functional …

The steady decline of physiological function and increased vulnerability to age-related
disorders are two features of the complicated biological process of ageing. As a key organ …

ABSTRACT A major challenge in the biology of aging is to understand how specific age-
onset pathologies relate to the overall health of the organism. The integrity of the intestinal …

Recent findings concerning Drosophila melanogaster intestinal pathology suggest that this
model is well suited for the study of intestinal stem cell physiology during aging, stress and …

Regenerative processes that maintain the function of the gastrointestinal (GI) epithelium are
critical for health and survival of multicellular organisms. In insects and vertebrates, intestinal …

Women live on average longer than men but have greater levels of late-life morbidity. We
have uncovered a substantial sex difference in the pathology of the aging gut in Drosophila …

In all metazoans, the intestinal tract is an essential organ to integrate nutritional signaling,
hormonal cues and immunometabolic networks. The dysregulation of intestinal epithelium …

Intestinal microbial communities participate in essential aspects of host biology, including
nutrient acquisition, development, immunity, and metabolism. During host aging, dramatic …