The availability of the next generation sequencing (NGS) technology in today's biomedical
research has provided new opportunities in scientific discovery of genetic information. The …

As one of the most recent advanced technologies developed for biomedical research, the
next generation sequencing (NGS) technology has opened more opportunities for scientific …

Following the breakthrough of the microarray technology, the next generation sequencing
(NGS) technology further advanced approaches in modern biomedical research. The high …

Summary In this 'Big Data'era, statisticians inevitably encounter data generated from various
disciplines. In particular, advances in bio‐technology have enabled scientists to produce …

Modeling the high-throughput next generation sequencing (NGS) data, resulting from
experiments with the goal of profiling tumor and control samples for the study of DNA copy …

Copy number variation (CNV) is a prevalent kind of genetic structural variation which leads
to an abnormal number of copies of large genomic regions, such as gain or loss of DNA …

The detection of copy number variation is important to understand complex diseases such
as autism, schizophrenia, cancer, etc. In this paper we propose a method to detect copy …

The chromosome copy number variation (CNV) is the deviation of genomic regions from
their normal copy number states, which may associate with many human diseases. Current …

Change‐point detection regains much attention recently for analyzing array or sequencing
data for copy number variation (CNV) detection. In such applications, the true signals are …

DNA copy number variations (CNVs) play an important role in the pathogenesis and
progression of cancer and confer susceptibility to a variety of human disorders. Array …