Fucosyltransferase 2: a genetic risk factor for primary sclerosing cholangitis and Crohn's disease—a comprehensive review

L Maroni, SFJ van de Graaf, SD Hohenester… - Clinical reviews in …, 2015 - Springer
Abstract Fucosyltransferase 2 (FUT2) mediates the inclusion of fucose in sugar moieties of
glycoproteins and glycolipids. ABO blood group antigens and host-microbe interactions are …

[HTML][HTML] Fucosyltransferase 2: a genetic risk factor for intestinal diseases

M Hu, X Zhang, J Li, L Chen, X He, T Sui - Frontiers in Microbiology, 2022 - frontiersin.org
The fucosyltransferase 2 gene (FUT2) mediates the synthesis of histoblood group antigens
(HBGA) that occur in vivo from multiple organs, particularly on the surface of intestinal …

[PDF][PDF] Knockout of the primary sclerosing cholangitis‐risk gene Fut2 causes liver disease in mice

L Maroni, SD Hohenester, SFJ van de Graaf… - …, 2017 - Wiley Online Library
The etiopathogenesis of primary sclerosing cholangitis is unknown. Genetic variants of
fucosyltransferase 2 (FUT2) have been identified in genome‐wide association studies as …

Association of fucosyltransferase 2 gene polymorphisms with inflammatory bowel disease in patients from Southeast China

H Wu, L Sun, D Lin, X Shao, S Xia… - … research and practice, 2017 - Wiley Online Library
Aims. Fucosyltransferase 2 (FUT2) gene potentially affects the constituent of intestinal
microbiota, which play a crucial role in the pathogenesis of inflammatory bowel disease …

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease

DPB McGovern, MR Jones, KD Taylor… - Human molecular …, 2010 - academic.oup.com
Genetic variation in both innate and adaptive immune systems is associated with Crohn's
disease (CD) susceptibility, but much of the heritability to CD remains unknown. We …

Association study of FUT2 (rs601338) with celiac disease and inflammatory bowel disease in the Finnish population

AS Parmar, N Alakulppi, P Paavola‐Sakki… - Tissue …, 2012 - Wiley Online Library
Homozygosity for a nonsense mutation in the fucosyltransferase 2 (FUT2) gene
(rs601338G> A) leads to the absence of ABH blood groups (FUT2 non‐secretor status) in …

[HTML][HTML] Association of fucosyltransferase 2 gene variants with ulcerative colitis in Han and Uyghur patients in China

A Aheman, HS Luo, F Gao - World Journal of Gastroenterology …, 2012 - ncbi.nlm.nih.gov
AIM: To investigate the contribution of fucosyltransferase 2 (FUT2) variants to the genetic
susceptibility and clinical heterogeneity of ulcerative colitis (UC) between Han and Uyghur …

Fut2 genotype is a risk factor for dominant stenosis and biliary candida infections in primary sclerosing cholangitis

C Rupp, K Friedrich, T Folseraas… - Alimentary …, 2014 - Wiley Online Library
Background A recent genome‐wide association study identified the FUT 2 secretor status
and genotype defined by the single‐nucleotide polymorphism rs601338 as potential genetic …

Association of FUT2 and ABO with Crohn's disease in Koreans

BD Ye, BM Kim, S Jung, HS Lee… - Journal of …, 2020 - Wiley Online Library
Abstract Background and Aim Fucosyltransferase 2 (FUT2) at 19q13 is a well‐established
susceptibility locus for Crohn's disease (CD) in Caucasians. FUT2 encodes α‐1, 2 …

Core fucosylation on T cells, required for activation of T-cell receptor signaling and induction of colitis in mice, is increased in patients with inflammatory bowel disease

H Fujii, S Shinzaki, H Iijima, K Wakamatsu, C Iwamoto… - Gastroenterology, 2016 - Elsevier
Background & Aims Attachment of a fucose molecule to the innermost N-glycan in a
glycoprotein (core fucosylation) regulates the activity of many growth factor receptors and …