Exposure to experimental preeclampsia in mice enhances the vascular response to future injury

D Pruthi, EV Khankin, RM Blanton, M Aronovitz… - …, 2015 - Am Heart Assoc
Cardiovascular disease (CVD) remains the leading killer of women in developed nations.
One sex-specific risk factor is preeclampsia, a syndrome of hypertension and proteinuria that …

Placental ischemia and resultant phenotype in animal models of preeclampsia

B LaMarca, LM Amaral, AC Harmon… - Current hypertension …, 2016 - Springer
Preeclampsia is new onset (or worsening of preexisting) hypertension that occurs during
pregnancy. It is accompanied by chronic inflammation, intrauterine growth restriction …

[HTML][HTML] Postpartum vascular dysfunction in the reduced uteroplacental perfusion model of preeclampsia

L Brennan, JS Morton, A Quon, ST Davidge - PLoS One, 2016 - journals.plos.org
Preeclampsia is a disorder affecting 2–8% of all pregnancies, characterized by gestational
hypertension (≥ 140/90 mmHg) and proteinuria (≥ 300 mg over 24 hours) diagnosed …

Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models

RA Khalil, JP Granger - American Journal of Physiology …, 2002 - journals.physiology.org
Normal pregnancy is associated with reductions in total vascular resistance and arterial
pressure possibly due to enhanced endothelium-dependent vascular relaxation and …

Animal models of pre‐eclampsia

N Sunderland, A Hennessy… - American journal of …, 2011 - Wiley Online Library
Citation Sunderland N, Hennessy A, Makris A. Animal models of pre‐eclampsia. Am J
Reprod Immunol 2010; 65: 533–541 The cardinal features of human pre‐eclampsia …

Plasma-mediated vascular dysfunction in the reduced uterine perfusion pressure model of preeclampsia: a microvascular characterization

SK Walsh, FA English, EJ Johns, LC Kenny - Hypertension, 2009 - Am Heart Assoc
Preeclampsia is associated with widespread maternal vascular dysfunction, which is thought
to be mediated by circulating factor (s). The aim of the study was to characterize vascular …

Animal models of preeclampsia: causes, consequences, and interventions

KL Gatford, PH Andraweera, CT Roberts, AS Care - Hypertension, 2020 - Am Heart Assoc
Preeclampsia is a common pregnancy complication, affecting 2% to 8% of pregnancies
worldwide, and is an important cause of both maternal and fetal morbidity and mortality …

Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats

ND Paauw, JA Joles, FT Spradley… - American Journal …, 2017 - journals.physiology.org
Women with a history of preeclampsia (PE) have an increased risk to develop
cardiovascular and renal diseases later in life, but the mechanisms underlying this effect are …

[HTML][HTML] A new mouse model to explore therapies for preeclampsia

A Ahmed, J Singh, Y Khan, SV Seshan, G Girardi - PloS one, 2010 - journals.plos.org
Background Pre-eclampsia, a pregnancy-specific multisystemic disorder is a leading cause
of maternal and perinatal mortality and morbidity. This syndrome has been known to medical …

Postpartum microvascular functional alterations following severe preeclampsia

LC Barr, J Pudwell, GN Smith - American Journal of …, 2021 - journals.physiology.org
Preeclampsia is associated with adverse maternal health outcomes later in life. Vascular
endothelial dysfunction has been previously described following preeclampsia. We …