Intense noise damages the cochlear organ of Corti, particularly the outer hair cells
(OHCs)[1]; however, this epithelium is not innervated by nociceptors of somatosensory …

Overexposure to intense sound can cause temporary or permanent hearing loss.
Postexposure recovery of threshold sensitivity has been assumed to indicate reversal of …

Acoustic overexposure can cause a permanent loss of auditory nerve fibers without
destroying cochlear sensory cells, despite complete recovery of cochlear thresholds, as …

The lives of an estimated ten million people in the United States are impacted by debilitating
cochlear noise injury acquired in leisure or occupational settings (Kopke et al., 2007) …

For decades, we have presumed the death of hair cells and spiral ganglion neurons are the
main cause of hearing loss and difficulties understanding speech in noise, but new findings …

Although protective effects of the cochlea's efferent feedback pathways have been well
documented, prior work has focused on hair cell damage and cochlear threshold elevation …

In experimental animal models of auditory hair cell (HC) loss, insults such as noise or
ototoxic drugs often lead to secondary changes or degeneration in non-sensory cells and …

Loud sounds damage the cochlea, the auditory receptor organ, reducing hearing sensitivity.
Previous studies demonstrate that the centrifugal olivocochlear pathways can moderately …

Cochlear synaptopathy is the noise-induced or age-related loss of ribbon synapses between
inner hair cells (IHCs) and auditory-nerve fibers (ANFs), first reported in CBA/CaJ mice …

Cochlear outer hair cells (OHCs) are known to uniquely participate in auditory processing
through their electromotility, and like inner hair cells, are also capable of releasing vesicular …