Recent neuroimaging studies suggest that the brain adapts with pain, as well as imparts risk
for developing chronic pain. Within this context, we revisit the concepts for nociception, acute …

Because pain signals potential harm to the organism, it immediately attracts attention and
motivates decisions and action. However, pain is also subject to motivations—an aspect that …

Cognitive self-regulation can strongly modulate pain and emotion. However, it is unclear
whether self-regulation primarily influences primary nociceptive and affective processes or …

Pain is an unpleasant experience. How the brain's affective neural circuits attribute this
aversive quality to nociceptive information remains unknown. By means of time-lapse in vivo …

Pain is fundamentally unpleasant, a feature that protects the organism by promoting
motivation and learning. Relief of aversive states, including pain, is rewarding. The …

Chronic pain remains one of the most persistent healthcare challenges in the world. To
advance pain treatment, experts have recently introduced research-driven subtypes of …

Neural mechanisms underlying nociception and pain perception are considered to serve the
ultimate goal of limiting tissue damage. However, since pain usually occurs in complex …

Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

Chronic pain conditions are associated with abnormalities in brain structure and function.
Moreover, some studies indicate that brain activity related to the subjective perception of …