Detection of human urinary 5-hydroxymethylcytosine by stable isotope dilution HPLC-MS/MS analysis
The sixth DNA base 5-hydroxymethylcytosine (5hmC) is the major oxidation product of the
epigenetic modification 5-methylcytosine (5mC), mediating DNA demethylation in mammals …
epigenetic modification 5-methylcytosine (5mC), mediating DNA demethylation in mammals …
Genomic mapping of 5-hydroxymethylcytosine in the human brain
Methylation at the 5-position of cytosine is a well-studied epigenetic pathway. In addition to 5-
methylcytosine (5mC), substantial amounts of 5-hydroxymethylcytosine (5hmC) also referred …
methylcytosine (5mC), substantial amounts of 5-hydroxymethylcytosine (5hmC) also referred …
[HTML][HTML] Hydroxymethylation and tumors: can 5-hydroxymethylation be used as a marker for tumor diagnosis and treatment?
T Xu, H Gao - Human genomics, 2020 - Springer
Methylcytosine (5mC) is considered as a common epigenetic modification that plays an
important role in the regulation of gene expression. At the same time, 5 …
important role in the regulation of gene expression. At the same time, 5 …
[HTML][HTML] Single-molecule quantification of 5-hydroxymethylcytosine for diagnosis of blood and colon cancers
Background The DNA modification 5-hydroxymethylcytosine (5hmC) is now referred to as
the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene …
the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene …
Sensitive and simultaneous determination of 5-methylcytosine and its oxidation products in genomic DNA by chemical derivatization coupled with liquid …
Cytosine methylation (5-methylcytosine, 5-mC) in genomic DNA is an important epigenetic
mark that has regulatory roles in diverse biological processes. 5-mC can be oxidized …
mark that has regulatory roles in diverse biological processes. 5-mC can be oxidized …
Distribution of 5‐hydroxymethylcytosine in different human tissues
W Li, M Liu - Journal of nucleic acids, 2011 - Wiley Online Library
5‐hydroxymethylcytosine (5‐hmC) is a modified form of cytosine recently found in
mammalians and is believed, like 5‐methylcytosine, to also play an important role in …
mammalians and is believed, like 5‐methylcytosine, to also play an important role in …
Hydrophilic material for the selective enrichment of 5-hydroxymethylcytosine and its liquid chromatography–tandem mass spectrometry detection
Y Tang, JM Chu, W Huang, J Xiong, XW Xing… - Analytical …, 2013 - ACS Publications
5-Methylcytosine (5-mC), an important epigenetic modification involved in development, can
be converted enzymatically to 5-hydroxymethylcytosine (5-hmC). 5-hmC is considered an …
be converted enzymatically to 5-hydroxymethylcytosine (5-hmC). 5-hmC is considered an …
A sensitive mass spectrometry method for simultaneous quantification of DNA methylation and hydroxymethylation levels in biological samples
T Le, KP Kim, G Fan, KF Faull - Analytical biochemistry, 2011 - Elsevier
The recent discovery of 5-hydroxymethyl-cytosine (5hmC) in embryonic stem cells and
postmitotic neurons has triggered the need for quantitative measurements of both 5-methyl …
postmitotic neurons has triggered the need for quantitative measurements of both 5-methyl …
Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA
DNA cytosine methylation (5mC) is highly abundant in mammalian cells and is associated
with transcriptional repression. Recently, hydroxymethylcytosine (hmC) has been detected …
with transcriptional repression. Recently, hydroxymethylcytosine (hmC) has been detected …
Quantification of 5-methylcytosine and 5-hydroxymethylcytosine in genomic DNA from hepatocellular carcinoma tissues by capillary hydrophilic-interaction liquid …
ML Chen, F Shen, W Huang, JH Qi, Y Wang… - Clinical …, 2013 - academic.oup.com
BACKGROUND 5-Methylcytosine (5-mC) is an important epigenetic modification involved in
development and is frequently altered in cancer. 5-mC can be enzymatically converted to 5 …
development and is frequently altered in cancer. 5-mC can be enzymatically converted to 5 …