Predominant role of water in native collagen assembly inside the bone matrix

RK Rai, C Singh, N Sinha - The Journal of Physical Chemistry B, 2015 - ACS Publications
Bone is one of the most intriguing biomaterials found in nature consisting of bundles of
collagen helixes, hydroxyapatite, and water, forming an exceptionally tough, yet lightweight …

Dehydration-induced structural changes in the collagen–hydroxyapatite interface in bone by high-resolution solid-state NMR spectroscopy

RK Rai, N Sinha - The Journal of Physical Chemistry C, 2011 - ACS Publications
Study of interactions among different components of amorphous biomaterial such as bone is
important to understand the mechanism of its formation and biomineralization process and …

Probing short and long‐range interactions in native collagen inside the bone matrix by BioSolids CryoProbe

N Tiwari, S Wegner, A Hassan… - Magnetic …, 2021 - Wiley Online Library
Solid‐state nuclear magnetic resonance is a promising technique to probe bone
mineralization and interaction of collagen protein in the native state. However, many of the …

Solid-state NMR studies on the organic matrix of bone

HD Xue, Y Yin, T He, H Song, J Li, X Kong - Nano Research, 2023 - Springer
Bone is a hierarchical architecture that consists of both inorganic and organic components.
The organic components, including collagen and numerous non-collagenous biomolecules …

Mechanistic Insights into the Role of Water in Backbone Dynamics of Native Collagen Protein by Natural Abundance 15N NMR Spectroscopy

C Singh, N Sinha - The Journal of Physical Chemistry C, 2016 - ACS Publications
Collagen being the most abundant animal protein is an integral component of muscle,
connective tissues, cartilage, and bones, having function to provide strength, load bearing …

Water scaffolding in collagen: Implications on protein dynamics as revealed by solid‐state NMR

AE Aliev, D Courtier‐Murias - Biopolymers, 2014 - Wiley Online Library
Solid‐state NMR studies of collagen samples of various origins confirm that the amplitude of
collagen backbone and sidechain motions increases significantly on increasing the water …

Elucidating the role of water in collagen self-assembly by isotopically modulating collagen hydration

G Giubertoni, L Feng, K Klein… - Proceedings of the …, 2024 - National Acad Sciences
Water is known to play an important role in collagen self-assembly, but it is still largely
unclear how water–collagen interactions influence the assembly process and determine the …

Structure analysis of collagen fibril at atomic-level resolution and its implications for intra-fibrillar transport in bone biomineralization

Z Xu, W Zhao, Z Wang, Y Yang, N Sahai - … Chemistry Chemical Physics, 2018 - pubs.rsc.org
Bone is a hierarchical biocomposite material in which a collagen fibril matrix self-assembled
in a three-dimensional (3-D) pseudohexagonal array controls many important processes in …

Collagen structure–function relationships from solid-state NMR spectroscopy

I Goldberga, R Li, MJ Duer - Accounts of chemical research, 2018 - ACS Publications
Conspectus The extracellular matrix of a tissue is as important to life as the cells within it. Its
detailed molecular structure defines the environment of a tissue's cells and thus their …

Time-resolved dehydration-induced structural changes in an intact bovine cortical bone revealed by solid-state NMR spectroscopy

P Zhu, J Xu, N Sahar, MD Morris, DH Kohn… - Journal of the …, 2009 - ACS Publications
Understanding the structure and structural changes of bone, a highly heterogeneous
material with a complex hierarchical architecture, continues to be a significant challenge …