Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: participation of antioxidant, nitrergic and …

GS Vasconcelos, NC Ximenes, CNS de Sousa… - Schizophrenia …, 2015 - Elsevier
Oxidative stress has important implications in schizophrenia. Alpha-lipoic acid (ALA) is a
natural antioxidant synthesized in human tissues with clinical uses. We studied the effect of …

Advantages of the alpha-lipoic acid association with chlorpromazine in a model of schizophrenia induced by ketamine in rats: behavioral and oxidative stress …

LRL Sampaio, FMS Cysne Filho, JC de Almeida… - Neuroscience, 2018 - Elsevier
Schizophrenia is a chronic mental disorder reported to compromise about 1% of the world's
population. Although its pathophysiological process is not completely elucidated, evidence …

Morin attenuates neurochemical changes and increased oxidative/nitrergic stress in brains of mice exposed to ketamine: prevention and reversal of schizophrenia-like …

B Ben-Azu, AO Aderibigbe, AEO Eneni, AM Ajayi… - Neurochemical …, 2018 - Springer
Previous studies have revealed that morin (MOR), a neuroactive bioflavonoid, with proven
psychotropic and neuroprotective properties reduced schizophrenic-like behaviors in mice …

Omega-3 prevents behavior response and brain oxidative damage in the ketamine model of schizophrenia

AI Zugno, HL Chipindo, AM Volpato, J Budni… - Neuroscience, 2014 - Elsevier
Supplementation with omega-3 has been identified as an adjunctive alternative for the
treatment of psychiatric disorders, in order to minimize symptoms. Considering the lack of …

Celecoxib and omega-3 fatty acids alone and in combination with risperidone affect the behavior and brain biochemistry in amphetamine-induced model of …

AES El-Sisi, SS Sokkar, MES El-Sayad… - Biomedicine & …, 2016 - Elsevier
The implications of oxidative stress and neuro-inflammation in the pathogenesis of
schizophrenia have been elucidated. Despite their effectiveness against positive symptoms …

Molecular mechanisms involved in the prevention and reversal of ketamine-induced schizophrenia-like behavior by rutin: the role of glutamic acid decarboxylase …

TO Oshodi, B Ben-Azu, IO Ishola, AM Ajayi… - Molecular biology …, 2021 - Springer
Mounting evidences have shown that nicotinamide adenine dinucleotide phosphate oxidase-
2 (Nox-2) pathway modifies glutamic-acid decarboxylase-67 (GAD 67)(GABAergic enzyme) …

Oxidative stress and role of antioxidant and ω-3 essential fatty acid supplementation in schizophrenia

SP Mahadik, D Evans, H Lal - Progress in Neuro-Psychopharmacology and …, 2001 - Elsevier
Oxidative stress and role of antioxidant and ω-3 essential fatty acid supplementation in
schizophrenia - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & …

Alpha-lipoic acid differently affects the reserpine-induced oxidative stress in the striatum and prefrontal cortex of rat brain

A Bilska, M Dubiel, M Sokołowska-Jez, E Lorenc-Koci… - Neuroscience, 2007 - Elsevier
Antioxidative properties of α-lipoic acid (LA) are widely investigated in different in vivo and in
vitro models. The aim of this study was to examine whether LA attenuates oxidative stress …

Effect of folic acid on oxidative stress and behavioral changes in the animal model of schizophrenia induced by ketamine

AI Zugno, L Canever, AS Heylmann, PG Wessler… - Journal of Psychiatric …, 2016 - Elsevier
Recent studies have shown benefits for the supplementation of folic acid in schizophrenic
patients. The aim of this study was to evaluate the effects of folic acid addition on adult rats …

[HTML][HTML] Different sub-anesthetic doses of ketamine increase oxidative stress in the brain of rats

L de Oliveira, CMS Spiazzi, T Bortolin… - Progress in Neuro …, 2009 - Elsevier
Schizophrenia is a complex neuropsychiatric disorder in which symptoms can be classified
as either positive, such as delusions and hallucinations, or negative, such as blunted affect …