Gut homeostasis plays an important role in maintaining the overall body health during aging.
Rapamycin, a specific inhibitor of mTOR, exerts prolongevity effects in evolutionarily diverse …

The FDA approved drug rapamycin can prolong lifespan in diverse species and delay the
onset of age-related disease in mammals. However, a number of fundamental questions …

Aging and age-related diseases occur in almost all organisms. Recently, it was discovered
that the inhibition of target of rapamycin complex 1 (TORC1), a conserved complex that …

Pharmacological therapies are promising interventions to slow down aging and reduce
multimorbidity in the elderly. Studies in animal models are the first step toward translation of …

The TOR (target of rapamycin) signaling pathway and the transcriptional factor Myc play
important roles in growth control. Myc acts, in part, as a downstream target of TOR to …

Target of rapamycin (TOR) is an evolutionarily conserved nutrient-sensing protein kinase
that regulates growth and metabolism in all eukaryotic cells. Studies in flies, worms, yeast …

Pharmacological attenuation of mTOR presents a promising route for delay of age-related
disease. Here we show that treatment of Drosophila with the mTOR inhibitor rapamycin …

The conserved target of rapamycin (TOR) pathway integrates signals from nutrient and
energy availability, growth factors and stress to regulate cell growth and proliferation …

Age-related changes to histone levels are seen in many species. However, it is unclear
whether changes to histone expression could be exploited to ameliorate the effects of …

Intestinal homeostasis is maintained by tightly controlled proliferation and differentiation of
tissue-resident multipotent stem cells during aging and regeneration, which ensures …