Mitochondria are a source of reactive oxygen species (ROS). Mitochondrial diseases are the
result of inherited defects in mitochondrially expressed genes. One potential …

There is significant evidence that the pathogenesis of several neurodegenerative diseases,
including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia (FRDA), multiple …

Oxidative stress arises when cellular antioxidant defences become overwhelmed by a
surplus generation of reactive oxygen species (ROS). Once this occurs, many cellular …

Oxidative stress is a phenotypic hallmark in several genetic disorders characterized by
cancer predisposition and/or propensity to premature ageing. Here we review the published …

A potential pivotal role for mitochondrial dysfunction in neurodegenerative diseases is
gaining increasing acceptance. Mitochondrial dysfunction leads to a number of deleterious …

In the last 4 years much progress has been made in the understanding of mitochondrial
disorders. Point-mutations, deletions and depletion of the mitochondrial genome are …

6.2. Point Mutations in tRNA Genes of mtDNA............................. 6.3. Point Mutations in rRNA
Genes of mtDNA............................. 6, 4. Point Mutations in Protein-Coding Genes of …

Respiratory chain dysfunction has been identified in several neurodegenerative disorders.
In Friedreich's ataxia (FA) and Huntington's disease (HD), where the respective mutations …

A number of epidemiological studies of mitochondrial disease have been carried out over
the last decade, clearly demonstrating that mitochondrial disorders are far more common …

The exact pathogenesis of Parkinson's disease (PD) is still unknown and proper
mechanisms that correspond to the disease remain unidentified. It is understood that PD is …