Host cell proteases: critical determinants of coronavirus tropism and pathogenesis
JK Millet, GR Whittaker - Virus research, 2015 - Elsevier
Coronaviruses are a large group of enveloped, single-stranded positive-sense RNA viruses
that infect a wide range of avian and mammalian species, including humans. The …
that infect a wide range of avian and mammalian species, including humans. The …
Priming time: how cellular proteases arm coronavirus spike proteins
M Hoffmann, H Hofmann-Winkler… - Activation of viruses by host …, 2018 - Springer
Coronaviruses are enveloped RNA viruses that infect mammals and birds. Infection of
humans with globally circulating human coronaviruses is associated with the common cold …
humans with globally circulating human coronaviruses is associated with the common cold …
Lysosomal proteases are a determinant of coronavirus tropism
Cell entry by coronaviruses involves two principal steps, receptor binding and membrane
fusion; the latter requires activation by host proteases, particularly lysosomal proteases …
fusion; the latter requires activation by host proteases, particularly lysosomal proteases …
Ready, set, fuse! The coronavirus spike protein and acquisition of fusion competence
T Heald-Sargent, T Gallagher - Viruses, 2012 - mdpi.com
Coronavirus-cell entry programs involve virus-cell membrane fusions mediated by viral
spike (S) proteins. Coronavirus S proteins acquire membrane fusion competence by …
spike (S) proteins. Coronavirus S proteins acquire membrane fusion competence by …
A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry
A Shulla, T Heald-Sargent, G Subramanya… - Journal of …, 2011 - Am Soc Microbiol
Spike (S) proteins, the defining projections of the enveloped coronaviruses (CoVs), mediate
cell entry by connecting viruses to plasma membrane receptors and by catalyzing …
cell entry by connecting viruses to plasma membrane receptors and by catalyzing …
[HTML][HTML] Mechanisms of coronavirus cell entry mediated by the viral spike protein
S Belouzard, JK Millet, BN Licitra, GR Whittaker - Viruses, 2012 - mdpi.com
Coronaviruses are enveloped positive-stranded RNA viruses that replicate in the cytoplasm.
To deliver their nucleocapsid into the host cell, they rely on the fusion of their envelope with …
To deliver their nucleocapsid into the host cell, they rely on the fusion of their envelope with …
Structure, function, and evolution of coronavirus spike proteins
F Li - Annual review of virology, 2016 - annualreviews.org
The coronavirus spike protein is a multifunctional molecular machine that mediates
coronavirus entry into host cells. It first binds to a receptor on the host cell surface through its …
coronavirus entry into host cells. It first binds to a receptor on the host cell surface through its …
Coronavirus spike protein and tropism changes
RJG Hulswit, CAM De Haan, BJ Bosch - Advances in virus research, 2016 - Elsevier
Coronaviruses (CoVs) have a remarkable potential to change tropism. This is particularly
illustrated over the last 15 years by the emergence of two zoonotic CoVs, the severe acute …
illustrated over the last 15 years by the emergence of two zoonotic CoVs, the severe acute …
Bat-to-human: spike features determining 'host jump'of coronaviruses SARS-CoV, MERS-CoV, and beyond
Both severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East
respiratory syndrome coronavirus (MERS-CoV) are zoonotic pathogens that crossed the …
respiratory syndrome coronavirus (MERS-CoV) are zoonotic pathogens that crossed the …
Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research
The severe acute respiratory syndrome (SARS) pandemic revealed that zoonotic
transmission of animal coronaviruses (CoV) to humans poses a significant threat to public …
transmission of animal coronaviruses (CoV) to humans poses a significant threat to public …