Cancer stem-like cells reside in hypoxic and slightly acidic tumor niches. Such
microenvironments favor more aggressive undifferentiated phenotypes and a slow growing" …

Glioblastoma is the most common malignant brain tumor. The heterogeneity at the cellular
level, metabolic specificities and plasticity of the cancer cells are a challenge for …

Glioblastoma is a highly heterogeneous brain tumor. The presence of cancer cells with stem-
like and tumor initiation/propagation properties contributes to poor prognosis. Glioblastoma …

Glioblastoma (GBM) is among the most lethal of all cancers. GBM consist of a
heterogeneous population of tumor cells among which a tumor-initiating and treatment …

Despite relevant progress obtained by multimodal treatment, glioblastoma (GBM), the most
aggressive primary brain tumor, is still incurable. The most encouraging advancement of …

Glioblastoma multiforme (GBM) is the deadliest and most common form of primary brain
tumor. Conventional treatments are ineffective at treating GBM due to the heterogeneous …

The anticancer drugs screening program is a long and expensive process. It is estimated
that only 5% of drugs entering clinical trials are approved by the FDA. Moreover, many of the …

We recently discovered a novel N-aryl tetracyclic dicarboximide MM0299 (1) with robust
activity against glioma stem-like cells that potently and selectively inhibits lanosterol …

Glioblastoma Multiforme (GBM) continues to have a poor patient prognosis despite optimal
standard of care. Glioma stem cells (GSCs) have been implicated as the presumed cause of …

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