Ginseng alleviates cyclophosphamide-induced hepatotoxicity via reversing disordered homeostasis of glutathione and bile acid

H Zhu, MH Long, J Wu, MM Wang, XY Li, H Shen… - Scientific reports, 2015 - nature.com
Cyclophosphamide (CP), a chemotherapeutic agent, is restricted due to its side effects,
especially hepatotoxicity. Ginseng has often been clinically used with CP in China, but …

Panax ginseng is superior to vitamin E as a hepatoprotector against cyclophosphamide-induced liver damage

A Abdelfattah-Hassan, SI Shalaby, SI Khater… - … Therapies in Medicine, 2019 - Elsevier
Abstract Background and aims Cyclophosphamide (CPh) is a frequently used drug, in
human and animals for its immunosuppressive and anticancer potential. However, it is …

Panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking …

SS Elblehi, MH Hafez, AH El-Far - Environmental Science and Pollution …, 2023 - Springer
Cypermethrin (CYP) is a synthetic pyrethroid utilized as an insecticide in agriculture and
various pest eradication programs. However, it induces numerous health hazards for …

Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity by suppressing inflammation and oxidative stress

Y Gao, J Yan, J Li, X Li, S Yang, N Chen… - Journal of Pharmacy …, 2021 - academic.oup.com
Objectives Improper usage of acetaminophen (APAP) leads to morbidity and also mortality
secondary to liver damage. Ginseng could suppress APAP-induced hepatotoxicity and …

Hepatoprotective effect of ginsenoside Rg1 from Panax ginseng on carbon tetrachloride‐induced acute liver injury by activating Nrf2 signaling pathway in mice

C Ning, X Gao, C Wang, X Huo, Z Liu… - Environmental …, 2018 - Wiley Online Library
Oxidative stress and inflammatory response are well known to be involved in the
pathogenesis of acute liver injury. This study was performed to examine the …

Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro

C Ning, X Gao, C Wang, Y Kong, Z Liu, H Sun… - Regulatory Toxicology …, 2018 - Elsevier
Acetaminophen (APAP) is a worldwide used drug for treating fever and pain. However,
APAP overdose is the leading cause of drug-induced liver injury. The purpose of the current …

[HTML][HTML] Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway

S Li, X Wang, Y Xiao, Y Wang, Y Wan, X Li, Q Li… - Ecotoxicology and …, 2021 - Elsevier
Environmental mercury is a concern for coastal ecosystem health, and exerts adverse effects
on human health. Despite the growing body of evidence showing the hepatoprotective roles …

[HTML][HTML] Ginsenoside Rk1 ameliorates paracetamol-induced hepatotoxicity in mice through inhibition of inflammation, oxidative stress, nitrative stress and apoptosis

JN Hu, XY Xu, W Li, YM Wang, Y Liu, Z Wang… - Journal of ginseng …, 2019 - Elsevier
Background Frequent overdose of paracetamol (APAP) has become the major cause of
acute liver injury. The present study was designed to evaluate the potential protective effects …

[HTML][HTML] Ginseng essence, a medicinal and edible herbal formulation, ameliorates carbon tetrachloride-induced oxidative stress and liver injury in rats

KH Lu, CY Weng, WC Chen, LY Sheen - Journal of Ginseng Research, 2017 - Elsevier
Background Ginseng essence (GE) is a formulation comprising four medicinal and edible
herbs including ginseng (Panax ginseng), American ginseng (Panax quinquefolius), lotus …

Glyphosate based-herbicide disrupts energy metabolism and activates inflammatory response through oxidative stress in mice liver

L Qi, YM Dong, H Chao, P Zhao, SL Ma, G Li - Chemosphere, 2023 - Elsevier
Glyphosate, the most widely used herbicide worldwide, has been reported to cause
hepatotoxicity. However, these systematic mechanisms remain poorly understood. Here, we …