Glioblastoma multiforme: Pathogenesis and treatment

C Alifieris, DT Trafalis - Pharmacology & therapeutics, 2015 - Elsevier
Abstract Each year, about 5–6 cases out of 100,000 people are diagnosed with primary
malignant brain tumors, of which about 80% are malignant gliomas (MGs). Glioblastoma …

Current trends in targeted therapies for glioblastoma multiforme

F Ohka, A Natsume… - Neurology research …, 2012 - Wiley Online Library
Glioblastoma multiforme (GBM) is one of the most frequently occurring tumors in the central
nervous system and the most malignant tumor among gliomas. Despite aggressive …

[HTML][HTML] Glioblastoma multiforme: State of the art and future therapeutics

TA Wilson, MA Karajannis, DH Harter - Surgical neurology …, 2014 - ncbi.nlm.nih.gov
Background: Glioblastoma multiforme (GBM) is the most common and lethal primary
malignancy of the central nervous system (CNS). Despite the proven benefit of surgical …

Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance

W Wu, JL Klockow, M Zhang, F Lafortune… - Pharmacological …, 2021 - Elsevier
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …

The landscape of novel therapeutics and challenges in glioblastoma multiforme: contemporary state and future directions

K Khaddour, TM Johanns, G Ansstas - Pharmaceuticals, 2020 - mdpi.com
Background: Glioblastoma multiforme is a malignant intracranial neoplasm that constitutes a
therapeutic challenge because of the associated high morbidity and mortality given the lack …

Glioblastoma multiforme: a review of therapeutic targets

OO Kanu, A Mehta, C Di, N Lin, K Bortoff… - Expert opinion on …, 2009 - Taylor & Francis
Glioblastoma is the commonest primary brain tumor, as well as the deadliest. Malignant
gliomas such as glioblastoma multiforme (GBM) present some of the greatest challenges in …

Emerging treatment strategies for glioblastoma multiforme

SK Carlsson, SP Brothers… - EMBO molecular medicine, 2014 - embopress.org
Glioblastoma multiforme (GBM) is the deadliest form of brain tumor with a more than 90% 5‐
year mortality. GBM has a paltry median survival of 12.6 months attributed to the unique …

Glioblastoma multiforme: a review of where we have been and where we are going

C Adamson, OO Kanu, AI Mehta, C Di… - Expert opinion on …, 2009 - Taylor & Francis
Malignant gliomas such as glioblastoma multiforme (GBM) present some of the greatest
challenges in the management of cancer patients worldwide, despite notable recent …

Glioblastoma Multiforme—A Look at the Past and a Glance at the Future

JL King, SR Benhabbour - Pharmaceutics, 2021 - mdpi.com
Gliomas are the most common type of brain tumor that occur in adults and children.
Glioblastoma multiforme (GBM) is the most common, aggressive form of brain cancer in …

Recent advances in the therapeutic strategies of glioblastoma multiforme

AF Aldoghachi, AF Aldoghachi, K Breyne, KH Ling… - Neuroscience, 2022 - Elsevier
Glioblastoma multiforme (GBM) is one of the most common, most formidable, and deadliest
malignant types of primary astrocytoma with a poor prognosis. At present, the standard of …