Baicalein triggers autophagy and inhibits the protein kinase B/mammalian target of rapamycin pathway in hepatocellular carcinoma HepG2 cells

YF Wang, T Li, ZH Tang, LL Chang, H Zhu… - Phytotherapy …, 2015 - Wiley Online Library
Baicalein (BA), isolated from the Chinese medicinal herb Scutellariae radix (Huangqin in
Chinese), is a flavonoid with various pharmacological effects. Herein, we found that BA only …

Baicalein induces beclin 1-and extracellular signal-regulated kinase-dependent autophagy in ovarian cancer cells

YF Wang, YL Xu, ZH Tang, T Li, LL Zhang… - The American Journal …, 2017 - World Scientific
Baicalein (BA), one of the major compounds isolated from the root of Scutellaria baicalensis
Gerogi, exhibits various pharmacological effects, such as anti-oxidant, anti-inflammatory …

[HTML][HTML] Inhibition of autophagy amplifies baicalein-induced apoptosis in human colorectal cancer

T Phan, VH Nguyen, MA Salazar, P Wong… - Molecular Therapy …, 2020 - cell.com
Baicalein is a Chinese herbal compound extracted from Scutellaria baicalensis that has anti-
tumor properties. The aim of this study was to elucidate the mechanisms of action of …

[HTML][HTML] AKT serine/threonine protein kinase modulates baicalin-triggered autophagy in human bladder cancer T24 cells

C Lin, SC Tsai, MT Tseng, SF Peng… - International …, 2013 - spandidos-publications.com
Baicalin is one of the major compounds in the traditional Chinese medicinal herb from
Scutellaria baicalensis Georgi. We investigated the molecular mechanisms of cell …

Baicalein induces apoptosis and autophagy via endoplasmic reticulum stress in hepatocellular carcinoma cells

Z Wang, C Jiang, W Chen, G Zhang… - BioMed research …, 2014 - Wiley Online Library
Background. Hepatocellular carcinoma (HCC) remains a disastrous disease and the
treatment for HCC is rather limited. Separation and identification of active compounds from …

Baicalein induces autophagy and apoptosis through AMPK pathway in human glioma cells

B Liu, L Ding, L Zhang, S Wang, Y Wang… - The American Journal …, 2019 - World Scientific
Baicalein (BAI) is a natural flavonoid. It has been shown that BAI has anticancer effects, but
the molecular mechanism is still unclear. The aim of the current study was to confirm …

Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro

W Yan, X Ma, X Zhao, S Zhang - Drug design, development and …, 2018 - Taylor & Francis
Purpose Baicalein, a widely used Chinese herbal medicine, has shown anticancer effects
on many types of human cancer cell lines. However, little is known about the underlying …

Anticancer effects of baicalein on hepatocellular carcinoma cells

YH Zheng, LH Yin, THM Grahn, AF Ye… - Phytotherapy …, 2014 - Wiley Online Library
The therapeutic potential of baicalein against hepatoma cells was evaluated in vitro and in
vivo. In cell viability assays, baicalein showed significant cytotoxicity against the …

Blocking autophagy enhances the apoptosis effect of bufalin on human hepatocellular carcinoma cells through endoplasmic reticulum stress and JNK activation

F Hu, J Han, B Zhai, X Ming, L Zhuang, Y Liu, S Pan… - Apoptosis, 2014 - Springer
Bufalin extracts are a part of traditional Chinese medicine, Chansu. In the current study, we
investigated the effect of bufalin on the proliferation of the human hepatocellular carcinoma …

Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of m TORC 1 complex components in human cancer cells

P Aryal, K Kim, PH Park, S Ham, J Cho… - The FEBS …, 2014 - Wiley Online Library
Baicalein, a flavonoid and aglycon hydrolyzed from baicalin, has anticancer properties in
several human carcinomas, but its molecular mechanisms of action remain unclear. Here …