Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …

Inflammasomes are multimeric protein complexes that regulate inflammatory responses and
pyroptotic cell death to exert host defense against microbes. Intracellular pattern-recognition …

Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

Inflammasomes are cytosolic multiprotein platforms assembled in response to invading
pathogens and other danger signals. Typically inflammasome complexes contain a sensor …

In response to injurious or infectious agents caspase-1 activating multiprotein complexes,
termed inflammasomes, assemble in the cytoplasm of cells. Activated caspase-1 cleaves the …

Innate immunity provides a first line of defense against invading pathogens. The host cell is
equipped with a set of germ-line-encoded pattern-recognition receptors (PRRs) that …

The extensively studied cytokine IL-1β is an important mediator of the inflammatory
response. However, dysregulated release of IL-1β can be detrimental and is attributed to the …

Inflammasomes are assembled by innate immune sensors that cells employ to detect a
range of danger signals and respond with pro‐inflammatory signalling. Inflammasomes …

The inflammasome is a macromolecular protein complex that mediates proteolytic cleavage
of pro-IL-1β and-IL-18 and induces cell death in the form of pyroptosis. Certain nucleotide …

Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …