Endothelial cells form the inner lining of blood vessels and regulate key blood vessel
functions including host defense reactions, vascular smooth muscle tone, angiogenesis, and …

Endothelial cells form the inner lining of blood vessels and are exposed to various factors
like hemodynamic conditions (shear stress, laminar, and turbulent flow), biochemical signals …

The advancement of in vitro techniques enables a better understanding of biological
processes and improves drug screening platforms. In vitro studies allow for enhanced …

The pathological complications of atherosclerosis, namely heart attacks and strokes, are the
leading cause of mortality in industrialized countries. The mechanisms governing …

These authors contributed equally to this work The microvasculature plays a key role in the
pathogenesis of sepsis, ARDS, multiorgan dysfunction, and a variety of other human …

Two key characteristics of the inflammatory response are the recruitment of leukocytes to
inflamed tissue as well as changes in vessel permeability. We explored the relationship …

As discussed in previous chapters, vascular-targeting via endothelial cell (EC)-expressed
molecules has potential for diagnostic and therapeutic applications in several human …

Endothelial cells represent important targets for therapeutic and diagnostic interventions in
many cardiovascular, pulmonary, neurological, inflammatory, and metabolic diseases …

The ultimate goal of much current research in angiogenesis and vascular biology is to
manipulate the cellular and intracellular signaling of endothelial cells, and thereby alter the …