Navigator‐3, a modulator of cell migration, may act as a suppressor of breast cancer progression
H Cohen‐Dvashi, N Ben‐Chetrit, R Russell… - EMBO molecular …, 2015 - embopress.org
Dissemination of primary tumor cells depends on migratory and invasive attributes. Here, we
identify Navigator‐3 (NAV 3), a gene frequently mutated or deleted in human tumors, as a …
identify Navigator‐3 (NAV 3), a gene frequently mutated or deleted in human tumors, as a …
Potential role of a navigator gene NAV3 in colorectal cancer
E Carlsson, A Ranki, L Sipilä, L Karenko… - British journal of …, 2012 - nature.com
Background: The recently described navigator proteins have a multifaceted role in
cytoskeletal dynamics. We report here on the relevance of one of them, navigator 3 (NAV3) …
cytoskeletal dynamics. We report here on the relevance of one of them, navigator 3 (NAV3) …
NAV3 copy number changes and target genes in basal and squamous cell cancers
P Maliniemi, E Carlsson, A Kaukola… - Experimental …, 2011 - Wiley Online Library
The neuron navigator 3 (NAV3) gene on chromosome 12q21 encodes a microtubule plus
end tracking protein and belongs to the navigator family of cytoskeletal regulators. Loss of …
end tracking protein and belongs to the navigator family of cytoskeletal regulators. Loss of …
[HTML][HTML] Nav1. 5 regulates breast tumor growth and metastatic dissemination in vivo
M Nelson, M Yang, R Millican-Slater, WJ Brackenbury - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract Voltage-gated Na+ channels (VGSCs) mediate action potential firing and regulate
adhesion and migration in excitable cells. VGSCs are also expressed in cancer cells. In …
adhesion and migration in excitable cells. VGSCs are also expressed in cancer cells. In …
Neuron navigator 2 overexpression indicates poor prognosis of colorectal cancer and promotes invasion through the SSH1L/cofilin-1 pathway
F Tan, H Zhu, Y Tao, N Yu, Q Pei, H Liu, Y Zhou… - Journal of Experimental …, 2015 - Springer
Abstract Background Neuron navigator 2 (NAV2) encodes a member of the neuron
navigator gene family, which plays a role in tumorigenesis and cell migration. However, the …
navigator gene family, which plays a role in tumorigenesis and cell migration. However, the …
Vangl-dependent Wnt/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis
K VanderVorst, CA Dreyer, J Hatakeyama… - Breast Cancer …, 2023 - Springer
Background In light of the growing appreciation for the role of collective cell motility in
metastasis, a deeper understanding of the underlying signaling pathways will be critical to …
metastasis, a deeper understanding of the underlying signaling pathways will be critical to …
Mammalian Navigators are microtubule plus‐end tracking proteins that can reorganize the cytoskeleton to induce neurite‐like extensions
J van Haren, K Draegestein, N Keijzer… - Cell motility and the …, 2009 - Wiley Online Library
Mammalian microtubule plus-end tracking proteins (+ TIPs) specifically associate with the
ends of growing microtubules.+ TIPs are involved in many cellular processes, including …
ends of growing microtubules.+ TIPs are involved in many cellular processes, including …
Overexpression of the VRK1 kinase, which is associated with breast cancer, induces a mesenchymal to epithelial transition in mammary epithelial cells
AM Mon, AC MacKinnon Jr, P Traktman - PLoS One, 2018 - journals.plos.org
Vaccinia-related kinase 1 (VRK1) is a pro-proliferative nuclear kinase. Mice engrafted with
VRK1-depleted MDA-MB-231 breast cancer cells have been shown to develop fewer distal …
VRK1-depleted MDA-MB-231 breast cancer cells have been shown to develop fewer distal …
The planar cell polarity protein Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase-dependent invasion
VA Cantrell, JR Jessen - Cancer letters, 2010 - Elsevier
Van Gogh-Like 2 (VANGL2) is a planar cell polarity protein essential for collective migration
during embryonic development, yet its contribution to tumor cell motility and invasion are …
during embryonic development, yet its contribution to tumor cell motility and invasion are …
The role of REST and HDAC2 in epigenetic dysregulation of Nav1. 5 and nNav1. 5 expression in breast cancer
NS Kamarulzaman, HD Dewadas, CY Leow… - Cancer cell …, 2017 - Springer
Background Increased expression of voltage-gated sodium channels (VGSCs) have been
implicated with strong metastatic potential of human breast cancer in vitro and in vivo where …
implicated with strong metastatic potential of human breast cancer in vitro and in vivo where …