Growth factors mediate their diverse biologic responses (regulation of cellular proliferation,
differentiation, migration and survival) by binding to and activating cell-surface receptors …

The epidermal growth factor (EGF) family of tyrosine kinase receptors (ErbB1,-2,-3, and-4)
and their ligands are involved in cell differentiation, proliferation, migration, and …

The ErbB receptor family, also known as the EGF receptor family or type I receptor family,
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …

This review article provides an overview on the most recent advances on the role of ErbB
receptors and growth factors of the epidermal growth factor (EGF)-family of peptides in …

Publisher Summary This chapter focuses on the role played by ErbB receptors in cancer
progression. Cancer patients, whose tumors have alterations in ErbB1 or ErbB2, tend to …

Cells are continuously exposed to diverse stimuli ranging from soluble endocrine and
paracrine factors, to signaling molecules on neighboring cells. It is of great importance that …

ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the
expression or activation of epidermal growth factor receptor and ERBB2 are altered in many …

ErbB receptor tyrosine kinases (RTKs) and their ligands have important roles in normal
development and in human cancer. Among the ErbB receptors only ErbB2 has no direct …

The erbB receptors, including the epidermal growth factor receptor (EGFR), erbB2 (also
known as HER2/neu), erbB3 (or HER3), and erbB4 (or HER4), are often aberrantly activated …

The overexpression and aberrant function of members of the erbB family of receptors,
particularly erbB1 (also known as epidermal growth factor receptor), and its ligands in many …