The concept of central insulin resistance and dysfunctional insulin signaling in Alzheimer's
disease (AD) has been developed by Siegfried Hoyer in 1985–2000. It is widely recognized …

Hyperinsulinemia as well as type II diabetes mellitus are among the risk factors for
Alzheimer's disease (AD). However, the molecular and cellular basis that link insulin …

An emerging body of evidence suggests that an increased prevalence of insulin
abnormalities and insulin resistance in Alzheimer's disease may contribute to the disease …

There is a growing interest in possible links between impaired insulin signaling and the
pathogenesis of Alzheimer's disease. Insulin and insulin-signaling mechanisms are …

Nosologically, Alzheimer disease may not be considered to be a single disorder in spite of a
common clinical phenotype. Only a small proportion of about 5% to 10% of all Alzheimer …

Growing evidence supports the concept that Alzheimer's disease (AD) is fundamentally a
metabolic disease with molecular and biochemical features that correspond with diabetes …

The incidence of Alzheimer's disease (AD) is significantly higher in people with diabetes.
Insulin and insulin receptor (IR) signaling intermediates are expressed in the brain. Insulin …

There is an urgent need for new ways to treat Alzheimer's disease (AD), the most common
cause of dementia in the elderly. Current therapies are modestly effective at treating the …

Interest in characterizing the role of impaired insulin actions in Alzheimer's disease (AD) and
vascular dementia is growing exponentially. This review details what is currently known …

Insulin plays a major neuroprotective and trophic function for cerebral cell population, thus
countering apoptosis, beta-amyloid toxicity, and oxidative stress; favoring neuronal survival; …