The protease/antiprotease balance determines influenza susceptibility and can be modified by oxidants and antioxidants
M Meyer - 2015 - cdr.lib.unc.edu
The respiratory epithelium functions as a central orchestrator to initiate and organize
responses to inhaled stimuli. Proteases and antiproteases are secreted from the respiratory …
responses to inhaled stimuli. Proteases and antiproteases are secreted from the respiratory …
Respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidants
M Meyer, I Jaspers - American Journal of Physiology-Lung …, 2015 - journals.physiology.org
The respiratory epithelium functions as a central orchestrator to initiate and organize
responses to inhaled stimuli. Proteases and antiproteases are secreted from the respiratory …
responses to inhaled stimuli. Proteases and antiproteases are secreted from the respiratory …
Oxidative Stress In Smokers Leads To A Protease/Antiprotease Imbalance, Enhancing Influenza A Virus Infection
M Meyer, MJ Kesic, L Brighton… - D36. INFLUENCES AND …, 2012 - atsjournals.org
Introduction: We have previously shown that cigarette smoking increases the susceptibility to
influenza A virus (IAV) infections. One potential reason for this increase in susceptibility to …
influenza A virus (IAV) infections. One potential reason for this increase in susceptibility to …
Inflammation Modulates The Human Airway Protease/Antiprotease Balance Contributing To Increased Influenza A Infection
MJ Kesic, M Meyer, RN Bauer… - B27. BALANCING ACT …, 2012 - atsjournals.org
Methods: We utilized our model of differentiated primary human nasal epithelial cells (NEC)
to determine the role inflammation in vitro plays in disrupting the protease/antiprotease …
to determine the role inflammation in vitro plays in disrupting the protease/antiprotease …
[HTML][HTML] Exposure to ozone modulates human airway protease/antiprotease balance contributing to increased influenza A infection
Exposure to oxidant air pollution is associated with increased respiratory morbidities and
susceptibility to infections. Ozone is a commonly encountered oxidant air pollutant, yet its …
susceptibility to infections. Ozone is a commonly encountered oxidant air pollutant, yet its …
Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers
M Meyer, RN Bauer, BD Letang… - … of Physiology-Lung …, 2014 - journals.physiology.org
A hallmark of cigarette smoking is a shift in the protease/antiprotease balance, in favor of
protease activity. However, it has recently been shown that smokers have increased …
protease activity. However, it has recently been shown that smokers have increased …
[图书][B] Airway epithelial cells increase secretory leukocyte protease inhibitormRNA levels in response to proteases and glucocorticoids
JM Abbinante-Nissen - 1994 - search.proquest.com
Airway inflammation, observed in a variety of airway diseases and following exposure to
environmental agents such as ozone, is associated with increases in inflammatory cell …
environmental agents such as ozone, is associated with increases in inflammatory cell …
[HTML][HTML] Hypoxia down-regulates expression of secretory leukocyte protease inhibitor in bronchial epithelial cells via TGF-β1
LI Påhlman, A Jögi, M Gram, M Mori… - BMC Pulmonary …, 2015 - Springer
Background Secretory leukocyte protease inhibitor (SLPI) is a protein with anti-protease and
antimicrobial properties that is constitutively secreted from the airway epithelium. The …
antimicrobial properties that is constitutively secreted from the airway epithelium. The …
Human SLPI inactivation after cigarette smoke exposure in a new in vivo model of pulmonary oxidative stress
E Cavarra, M Lucattelli, F Gambelli… - … of Physiology-Lung …, 2001 - journals.physiology.org
The role of oxidative stress in inactivating antiproteases is the object of debate. To address
this question, we developed an in vivo model of pulmonary oxidative stress induced by …
this question, we developed an in vivo model of pulmonary oxidative stress induced by …
How SLPI soothes
HL Van Epps - The Journal of Experimental Medicine, 2005 - ncbi.nlm.nih.gov
Organs such as the lung that are continuously exposed to inhaled microbes must be
carefully guarded against excessive inflammation. A new study by Taggart and colleagues …
carefully guarded against excessive inflammation. A new study by Taggart and colleagues …