miR-185 plays an anti-hypertrophic role in the heart via multiple targets in the calcium-signaling pathways

JO Kim, DW Song, EJ Kwon, SE Hong, HK Song… - PLoS …, 2015 - journals.plos.org
MicroRNA (miRNA) is an endogenous non-coding RNA species that either inhibits RNA
translation or promotes degradation of target mRNAs. miRNAs often regulate cellular …

miR-218 involvement in cardiomyocyte hypertrophy is likely through targeting REST

JJ Liu, CM Zhao, ZG Li, YM Wang, W Miao… - International Journal of …, 2016 - mdpi.com
MicroRNAs (miRNAs) have been identified as key players in cardiomyocyte hypertrophy,
which is associated with significant risks of heart failure. However, many microRNAs are still …

MicroRNA-30b-5p is involved in the regulation of cardiac hypertrophy by targeting CaMKIIδ

J He, S Jiang, F Li, X Zhao, E Chu… - Journal of …, 2013 - journals.sagepub.com
Background MicroRNAs (miRNAs) participate in the regulation of cardiac hypertrophy.
However, it remains largely unknown as to how miRNAs are integrated into the hypertrophic …

MicroRNAs play an essential role in the development of cardiac hypertrophy

D Sayed, C Hong, IY Chen, J Lypowy… - Circulation …, 2007 - Am Heart Assoc
MicroRNAs are naturally existing, small, noncoding RNA molecules that downregulate
posttranscriptional gene expression. Their expression pattern and function in the heart …

MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors

J Ganesan, D Ramanujam, Y Sassi, A Ahles… - Circulation, 2013 - Am Heart Assoc
Background—Several microRNAs (miRs) have been shown to regulate gene expression in
the heart, and dysregulation of their expression has been linked to cardiac disease. miR-378 …

MicroRNAs control gene expression: importance for cardiac development and pathophysiology

D Catalucci, MVG Latronico… - Annals of the New York …, 2008 - Wiley Online Library
Growing evidence indicates that microRNAs (miRNAs) are involved in a variety of basic
biological processes, including cell proliferation, apoptosis, stress response, hematopoesis …

MiRNA‐339‐5p promotes isoproterenol‐induced cardiomyocyte hypertrophy by targeting VCP to activate the mTOR signaling

X Bi, Y Zhang, Y Yu, J Yuan, S Xu, F Liu… - Cell Biology …, 2022 - Wiley Online Library
MicroRNAs (miRNAs) regulate multiple biological processes and participate in various
cardiovascular diseases. This study aims to investigate the role of miR‐339‐5p in …

miR-222 inhibits pathological cardiac hypertrophy and heart failure

X Liu, H Li, MH Hastings, C Xiao… - Cardiovascular …, 2024 - academic.oup.com
Aims Physiological cardiac hypertrophy occurs in response to exercise and can protect
against pathological stress. In contrast, pathological hypertrophy occurs in disease and often …

MicroRNAs target gene and signaling pathway by bioinformatics analysis in the cardiac hypertrophy

E Shen, X Diao, C Wei, Z Wu, L Zhang, B Hu - Biochemical and biophysical …, 2010 - Elsevier
Cardiac hypertrophy is a physiological adaptive response of the heart to diverse
pathophysiological stimuli. Initially, it may be adaptive to normalize wall stress and to …

MiR‐221 promotes cardiac hypertrophy in vitro through the modulation of p27 expression

C Wang, S Wang, P Zhao, X Wang… - Journal of cellular …, 2012 - Wiley Online Library
Cardiac hypertrophy has been known as an independent predictor for cardiovascular
morbidity and mortality. Molecular mechanisms underlying the development of heart failure …