[HTML][HTML] Bispecific antibodies

RE Kontermann, U Brinkmann - Drug discovery today, 2015 - Elsevier
Bispecific antibodies (bsAbs) combine specificities of two antibodies and simultaneously
address different antigens or epitopes. BsAbs with 'two-target'functionality can interfere with …

Bispecific antibodies: a mechanistic review of the pipeline

AF Labrijn, ML Janmaat, JM Reichert… - Nature reviews Drug …, 2019 - nature.com
The term bispecific antibody (bsAb) is used to describe a large family of molecules designed
to recognize two different epitopes or antigens. BsAbs come in many formats, ranging from …

Bispecific antibodies

U Brinkmann, RE Kontermann - Science, 2021 - science.org
Bispecific antibodies (bsAbs) bind two different epitopes on the same or different antigens.
Through this dual specificity for soluble or cell-surface antigens, bsAbs exert activities …

Biology drives the discovery of bispecific antibodies as innovative therapeutics

S Nie, Z Wang, M Moscoso-Castro… - Antibody …, 2020 - academic.oup.com
ABSTRACT A bispecific antibody (bsAb) is able to bind two different targets or two distinct
epitopes on the same target. Broadly speaking, bsAbs can include any single molecule …

The present and future of bispecific antibodies for cancer therapy

C Klein, U Brinkmann, JM Reichert… - Nature Reviews Drug …, 2024 - nature.com
Bispecific antibodies (bsAbs) enable novel mechanisms of action and/or therapeutic
applications that cannot be achieved using conventional IgG-based antibodies …

The state of the art of bispecific antibodies for treating human malignancies

S Wang, K Chen, Q Lei, P Ma, AQ Yuan… - EMBO molecular …, 2021 - embopress.org
Bispecific antibodies (bsAb) that target two independent epitopes or antigens have been
extensively explored in translational and clinical studies since they were first developed in …

[HTML][HTML] Clinical pharmacology and translational aspects of bispecific antibodies

A Trivedi, S Stienen, M Zhu, H Li… - Clinical and …, 2017 - ncbi.nlm.nih.gov
Development of bispecific antibodies (BsAbs) as therapeutic agents has recently attracted
significant attention, and investments in this modality have been steadily increasing. This …

Dual targeting strategies with bispecific antibodies

R Kontermann - MAbs, 2012 - Taylor & Francis
Monoclonal antibodies are widely used for the treatment of cancer, inflammatory and
infectious diseases and other disorders. Most of the marketed antibodies are monospecific …

[HTML][HTML] Bispecific antibodies: from research to clinical application

J Ma, Y Mo, M Tang, J Shen, Y Qi, W Zhao… - Frontiers in …, 2021 - frontiersin.org
Bispecific antibodies (BsAbs) are antibodies with two binding sites directed at two different
antigens or two different epitopes on the same antigen. The clinical therapeutic effects of …

[HTML][HTML] A review of bispecific antibodies and antibody constructs in oncology and clinical challenges

FV Suurs, MN Lub-de Hooge, EGE de Vries… - Pharmacology & …, 2019 - Elsevier
Bispecific antibodies (bsAbs) are antibodies that bind two distinct epitopes to cancer.. For
use in oncology, one bsAb has been approved and 57 bsAbs are in clinical trials, none of …