Ginkgolide B revamps neuroprotective role of apurinic/apyrimidinic endonuclease 1 and mitochondrial oxidative phosphorylation against Aβ25–35‐induced …
N Kaur, M Dhiman, JR Perez‐Polo… - Journal of …, 2015 - Wiley Online Library
Accumulating evidence points to roles for oxidative stress, amyloid beta (Aβ), and
mitochondrial dysfunction in the pathogenesis of Alzheimer's disease (AD). In neurons, the …
mitochondrial dysfunction in the pathogenesis of Alzheimer's disease (AD). In neurons, the …
[HTML][HTML] Ginkgolide B‑induced AMPK pathway activation protects astrocytes by regulating endoplasmic reticulum stress, oxidative stress and energy metabolism …
J Wang, Y Ding, L Zhuang… - Molecular …, 2021 - spandidos-publications.com
Ginkgolide B (GB), the diterpenoid lactone compound isolated from the extracts of Ginkgo
biloba leaves, significantly improves cognitive impairment, but its potential pharmacological …
biloba leaves, significantly improves cognitive impairment, but its potential pharmacological …
[HTML][HTML] Geniposide Protects Primary Cortical Neurons against Oligomeric Aβ1-42-Induced Neurotoxicity through a Mitochondrial Pathway
C Zhao, C Lv, H Li, S Du, X Liu, Z Li, W Xin, W Zhang - PLoS One, 2016 - journals.plos.org
Mitochondrial dysfunction plays a key role in the progression of Alzheimer's disease (AD).
The accumulation of amyloid-beta peptide (Aβ) in the brains of AD patients is thought to be …
The accumulation of amyloid-beta peptide (Aβ) in the brains of AD patients is thought to be …
EGb761 ameliorates cell necroptosis by attenuating RIP1-mediated mitochondrial dysfunction and ROS production in both in vivo and in vitro models of Alzheimer's …
JL Tu, WP Chen, ZJ Cheng, G Zhang, QH Luo, M Li… - Brain research, 2020 - Elsevier
Objectives To investigate the neuroprotective effect of Gingko biloba extract 761 (EGb761) in
Alzheimer's disease (AD) models both in vivo and in vitro and the underlying molecular …
Alzheimer's disease (AD) models both in vivo and in vitro and the underlying molecular …
PEG–PEI/siROCK2 Protects Against Aβ42-Induced Neurotoxicity in Primary Neuron Cells for Alzheimer Disease
Y Liu, X Yang, Q Lei, Z Li, J Hu, X Wen, H Wang… - Cellular and molecular …, 2015 - Springer
Gene therapy that targets the ROCK2 gene has yielded promising results in the treatment of
AD. Our previous study indicated that PEG–PEI/siROCK2 could effectively suppress ROCK2 …
AD. Our previous study indicated that PEG–PEI/siROCK2 could effectively suppress ROCK2 …
[HTML][HTML] Genistein protects against Aβ25–35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers
F You, Q Li, G Jin, Y Zheng, J Chen, H Yang - BMC neuroscience, 2017 - Springer
Background Deposition of aggregated amyloid beta (Aβ) protein is hallmark of Alzheimer's
disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen …
disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen …
Eriodictyol attenuates β-amyloid 25–35 peptide-induced oxidative cell death in primary cultured neurons by activation of Nrf2
X Jing, H Shi, X Zhu, X Wei, M Ren, M Han… - Neurochemical …, 2015 - Springer
Oxidative stress plays an important role in the pathogenesis of neurodegenerative diseases,
including Alzheimer's disease (AD). Eriodictyol, a flavonoid isolated from the Chinese herb …
including Alzheimer's disease (AD). Eriodictyol, a flavonoid isolated from the Chinese herb …
Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway
X Zhao, Y Zou, H Xu, L Fan, H Guo, X Li, G Li, X Zhang… - Brain research, 2012 - Elsevier
One hallmark of Alzheimer's disease (AD) is amyloid-beta (Aβ) deposition, which can initiate
a cascade of oxidative events that may result in neuronal death. The present study aimed to …
a cascade of oxidative events that may result in neuronal death. The present study aimed to …
Phytochemical ginkgolide B attenuates amyloid-β 1-42 induced oxidative damage and altered cellular responses in human neuroblastoma SH-SY5Y cells
Oxidative stress is an upsurge in reactive oxygen/nitrogen species (ROS/RNS), which
aggravates damage to cellular components viz. lipids, proteins, and nucleic acids resulting …
aggravates damage to cellular components viz. lipids, proteins, and nucleic acids resulting …
Paeoniflorin attenuates Aβ25-35-induced neurotoxicity in PC12 cells by preventing mitochondrial dysfunction
J Li, X Ji, J Zhang, G Shi, X Zhu, K Wang - Folia Neuropathologica, 2014 - termedia.pl
The pathogenic mechanism of neurodegenerative brain disorder such as Alzheimer's
disease (AD) has been still far from clearly understood. Previous research has identified that …
disease (AD) has been still far from clearly understood. Previous research has identified that …