Adipose tissue is a pivotal organ determining longevity, due largely to its role in maintaining
whole-body energy homeostasis and insulin sensitivity. SIRT1 is a NAD-dependent protein …

SIRT1, a longevity regulator and NAD+-dependent deacetylase, plays a critical role in
promoting metabolic fitness associated with calorie restriction and healthy ageing. Using a …

Adipose tissue is an important endocrine organ that regulates metabolism, immune
response and aging in mammals. Healthy adipocytes promote tissue homeostasis and …

Sir2/Sirt1, a mediator of longevity in several animal models, is a member of the sirtuin family
of type III histone deacetylases. Its non-histone substrates include a group of regulatory …

Caloric restriction (CR) has been shown to prevent the onset of insulin resistance and to
delay age-related physiological decline in mammalian organisms. SIRT1, a NAD+ …

The NAD+‐dependent SIRT6 deacetylase is a therapeutic candidate against the emerging
metabolic syndrome epidemic. SIRT6, whose deficiency in mice results in premature aging …

Mitochondrial dysfunction in adipose tissue is involved in the pathophysiology of obesity-
induced systemic metabolic complications, such as type 2 diabetes, insulin resistance, and …

SIRT1 is a highly-conserved NAD+-dependent protein deacetylase that plays essential roles
in the regulation of energy metabolism, genomic stability, and stress response. Although the …

Sirtuins (Sirt1–Sirt7) are NAD+-dependent protein deacetylases/ADP ribosyltransferases,
which play decisive roles in chromatin silencing, cell cycle regulation, cellular differentiation …

Objective Adipose tissue is the primary site for lipid deposition that protects the organisms in
cases of nutrient excess during obesogenic diets. The histone deacetylase Sirtuin 1 (SIRT1) …