Objective. Activation of membrane receptor guanylate cyclase-C (GC-C) is implicated in
gastrointestinal fluid and electrolyte balance, preservation of intestinal barrier integrity, anti …

The transmembrane receptor guanylate cyclase-C (GC-C) signaling pathway has been
implicated in several gastrointestinal disorders. Activation of GC-C via guanylin (Gn) and …

Abstract Guanylate cyclase C (GUCY2C or GC-C) and its ligands, guanylin (GUCA2A or Gn)
and uroguanylin (GUCA2B or Ugn), are expressed in intestinal epithelial cells and regulate …

Background Guanylate Cyclase C (GC-C; Gucy2c) is a transmembrane receptor expressed
in intestinal epithelial cells. Activation of GC-C by its secreted ligand guanylin stimulates …

Functional gastrointestinal disorders (FGIDs) and IBDs are two of the most prevalent
disorders of the GI tract and consume a significant proportion of healthcare resources …

Abstract Background Guanylate Cyclase C (GC-C) is an apically-oriented transmembrane
receptor that is expressed on epithelial cells of the intestine. Activation of GC-C by the …

Activating mutations in receptor guanylyl cyclase C (GC-C), the target of gastrointestinal
peptide hormones guanylin and uroguanylin, and bacterial heat-stable enterotoxins cause …

Guanylyl cyclase C (GC-C) is predominantly expressed in intestinal epithelial cells and
serves as the receptor for the gastrointestinal hormones guanylin and uroguanylin, and the …

The natural hormone uroguanylin regulates intestinal fluid homeostasis and bowel function
through activation of guanylate cyclase-C (GC-C), resulting in increased intracellular cyclic …

Background Guanylyl Cyclase C (GCC) signaling via uroguanylin (UGN) and guanylin
activation is a critical mediator of intestinal fluid homeostasis, intestinal cell …