The amyloid cascade hypothesis for the pathogenesis of Alzheimer's disease (AD) was
proposed over twenty years ago. However, the mechanisms of neurodegeneration and …

Mitochondrial epigenetic alterations are closely related to Alzheimer's disease (AD), which is
described in this review. Reports of the alteration of mitochondrial DNA (mtDNA) methylation …

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …

Mitochondria, the centers of energy metabolism, have been shown to participate in
epigenetic regulation of neurodegenerative diseases. Epigenetic modification of nuclear …

Mitochondrial impairment and increased oxidative stress are common features in
neurodegenerative disorders, leading researchers to speculate that epigenetic changes in …

Although there is a substantial literature that mitochondria have a crucial role in the aging
process, the mechanism has remained elusive. The role of reactive oxygen species …

Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

Considerable evidence suggests that mitochondrial dysfunction occurs early in Alzheimer's
disease, both in affected brain regions and in leukocytes, potentially precipitating …

Alzheimer's is a neurodegenerative disease with a complex and progressive pathological
phenotype characterized first by hypometabolism and impaired mitochondrial bioenergetics …

Alzheimer's Disease (AD) is the main cause of dementia and it is defined by cognitive
decline coupled to extracellular deposit of amyloid-beta protein and intracellular …