Friedreich's ataxia (FA) is associated with progressive cardiac hypertrophy resulting from a
genetic abnormality in the frataxin gene. Cardiac involvement is the most common cause of …

Background: Friedreich's ataxia encodes a protein of unknown function, frataxin. The loss of
frataxin is caused by a large GAA trinucleotide expansion in the first intron of the gene …

Friedreich's ataxia (FRDA) is a neuro-degenerative disease causing limb and gait ataxia
and hypertrophic cardiomyopathy. It results from a triplet expansion in the first intron of the …

Friedreich ataxia (FA), the most common form of degenerative ataxia, is thought to be
caused by respiratory deficiency due to mitochondrial iron accumulation and oxidative …

Sažetak Friedreich's ataxia (FRDA) is the most common autosomal recessive ataxia. This
neurodegenerative disease is caused by expansion of a GAA triplet repeat located within …

Friedreich ataxia (FA) is an autosomal recessively inher-ited neurodegenerative disease
that most often presents in childhood or in young adulthood. A substantial proportion of …

Friedreich ataxia (FA) is an autosomal recessively inher-ited neurodegenerative disease
that most often presents in childhood or in young adulthood. A substantial proportion of …

Background Friedreich's ataxia (FA) is a progressive, multisystem, degenerative disorder
caused by a reduction in frataxin. Loss of frataxin results in mitochondrial dysfunction and …

This paper reviews the history and pre-clinical development of idebenone and summarises
the results of clinical studies, published from 1999 to 2008, on the use of idebenone in the …

Background: Friedreich's ataxia is an autosomal recessive neurodegenerative disease
where impaired mitochondrial function and excessive production of free radicals play a …