Metabolic connection of inflammatory pain: pivotal role of a pyruvate dehydrogenase kinase-pyruvate dehydrogenase-lactic acid axis
Pyruvate dehydrogenase kinases (PDK1–4) are mitochondrial metabolic regulators that
serve as decision makers via modulation of pyruvate dehydrogenase (PDH) activity to …
serve as decision makers via modulation of pyruvate dehydrogenase (PDH) activity to …
Pyruvate dehydrogenase kinase-mediated glycolytic metabolic shift in the dorsal root ganglion drives painful diabetic neuropathy
The dorsal root ganglion (DRG) is a highly vulnerable site in diabetic neuropathy. Under
diabetic conditions, the DRG is subjected to tissue ischemia or lower ambient oxygen …
diabetic conditions, the DRG is subjected to tissue ischemia or lower ambient oxygen …
Metabolic reprogramming by the pyruvate dehydrogenase kinase–lactic acid axis: Linking metabolism and diverse neuropathophysiologies
Emerging evidence indicates that there is a complex interplay between metabolism and
chronic disorders in the nervous system. In particular, the pyruvate dehydrogenase (PDH) …
chronic disorders in the nervous system. In particular, the pyruvate dehydrogenase (PDH) …
Regulation of mitochondrial function by Epac2 contributes to acute inflammatory hyperalgesia
DJ Goode, DC Molliver - Journal of Neuroscience, 2021 - Soc Neuroscience
Gαs-coupled receptors signaling through cAMP provide a key mechanism for the
sensitization of nociceptive sensory neurons, and the cAMP effector Epac has been …
sensitization of nociceptive sensory neurons, and the cAMP effector Epac has been …
[HTML][HTML] Platelet-rich plasma improves chronic inflammatory pain by inhibiting PKM2-mediated aerobic glycolysis in astrocytes
X Wei, XH Jin, XW Meng, J Hua, FH Ji… - Annals of …, 2020 - ncbi.nlm.nih.gov
Background Astrocytes are highly glycolytic cells that play a crucial role in chronic pain.
Recently it has been found that inflammation and metabolism are related to the inflammatory …
Recently it has been found that inflammation and metabolism are related to the inflammatory …
Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
Hypothalamic inflammation plays an important role in disrupting feeding behavior and
energy homeostasis as well as in the pathogenesis of obesity and diabetes. Here, we show …
energy homeostasis as well as in the pathogenesis of obesity and diabetes. Here, we show …
Neuroinflammation and comorbidity of pain and depression
Comorbid depression and chronic pain are highly prevalent in individuals suffering from
physical illness. Here, we critically examine the possibility that inflammation is the common …
physical illness. Here, we critically examine the possibility that inflammation is the common …
Astrocyte-neuron lactate transport in the ACC contributes to the occurrence of long-lasting inflammatory pain in male mice
Y Wang, Y Peng, C Zhang, X Zhou - Neuroscience letters, 2021 - Elsevier
Lactate transport is an important means of communication between astrocytes and neurons
and is implicated in a variety of neurobiological processes. However, the connection …
and is implicated in a variety of neurobiological processes. However, the connection …
Co-players in chronic pain: neuroinflammation and the tryptophan-kynurenine metabolic pathway
Chronic pain is an unpleasant sensory and emotional experience that persists or recurs
more than three months and may extend beyond the expected time of healing. Recently …
more than three months and may extend beyond the expected time of healing. Recently …
Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes
Painful diabetic neuropathy (PDN) is a devastating neurological complication of diabetes.
Methylglyoxal (MG) is a reactive metabolite whose elevation in the plasma corresponds to …
Methylglyoxal (MG) is a reactive metabolite whose elevation in the plasma corresponds to …