The immediate-early response mediates cell fate in response to a variety of extracellular
stimuli and is dysregulated in many cancers. However, the specificity of the response across …

The promoters of immediate early genes (IEGs) are rapidly activated in response to an
external stimulus. These genes, also known as primary response genes, have been …

During cellular processes such as differentiation or response to external stimuli, cells exhibit
dynamic changes in their gene expression profiles. Single-cell RNA sequencing (scRNA …

Defining the transcriptional dynamics of a temporal process such as cell differentiation is
challenging owing to the high variability in gene expression between individual cells. Time …

Gene expression programs are dynamic, eg the cell cycle, response to stimuli, normal
differentiation and development, etc. However, nearly all techniques for profiling gene …

Co‐and post‐transcriptional regulation of gene expression is complex and multifaceted,
spanning the complete RNA lifecycle from genesis to decay. High‐throughput profiling of the …

Most functional genomic studies are conducted in steady-state conditions, therefore
providing a description of molecular processes at a particular moment of cell differentiation …

Activities of transcription factors (TFs) are temporally modulated to regulate dynamic cellular
processes, including development, homeostasis, and disease. Recent developments of …

Gene transcription mediated by RNA polymerase II (pol-II) is a key step in gene expression.
The dynamics of pol-II moving along the transcribed region influence the rate and timing of …

Global changes in transcriptional regulation and RNA metabolism are crucial features of
cancer development. However, little is known about the role of the core promoter in defining …