Early embryonic loss and altered gene expression in in vitro produced blastocysts are
believed to be partly caused by aberrant DNA methylation. However, specific embryonic …

Background Aberrant DNA methylation patterns of genes required for development are
common in in vitro produced embryos. In this regard, we previously identified altered DNA …

Background The timing of the first cell divisions may predict the developmental potential of
an embryo, including its ability to establish pregnancy. Besides differences related to …

During the transit through the oviduct, the early embryo initiates an extensive DNA
methylation reprogramming of its genome. Given that these epigenetic modifications are …

Early embryonic development in the pig requires DNA methylation remodeling of the
maternal and paternal genomes. Aberrant remodeling, which can be exasperated by in vitro …

DNA methylation undergoes drastic fluctuation during early mammalian embryogenesis.
The dynamics of global DNA methylation in bovine embryos, however, have mostly been …

Background Infertility in dairy cattle is a concern where reduced fertilization rates and high
embryonic loss are contributing factors. Studies of the paternal contribution to reproductive …

STUDY QUESTION Do embryos with different developmental competence exhibit different
DNA methylation profiles at the blastocyst stage? SUMMARY ANSWER We established …

Background Oocytes and early embryos contain minute amounts of DNA, RNA and proteins,
making the study of early mammalian development highly challenging. The study of the …

Background Assisted reproductive technologies (ART) are widely used to treat fertility issues
in humans and for the production of embryos in mammalian livestock. The use of these …