Background Oxidative stress is strongly associated with aging and age-related diseases and
plays a crucial role in endothelial dysfunction development. Aim To better understand the …

Accumulating evidence has shown that diabetes accelerates aging and endothelial cell
senescence is involved in the pathogenesis of diabetic vascular complications, including …

As one of the main risk factors for cardiovascular diseases, ageing plays an important role in
the alterations of vascular structure and function. Early vascular ageing refers to a condition …

Yeast Sir2 plays critical roles in gene silencing, stress resistance and longevity. Mammalian
Sirt1 NAD+-dependent protein deacetylase, the closest homolog of Sir2, regulates cell cycle …

Age is a risk factor for cardiovascular disease, suggesting a causal relationship between
age-related changes and vascular damage. Endothelial dysfunction is an early …

Environmental stressors as well as genetic modifications are known to enhance oxidative
stress and aging processes. Mitochondrial and nuclear dysfunctions contribute to the onset …

In diabetes, some of the cellular changes are similar to aging. We hypothesized that
hyperglycemia accelerates aging-like changes in the endothelial cells (ECs) and tissues …

SIRT1/eNOS Axis as a Potential Target against Vascular Senescence, Dysfunction and
Atherosclerosis Page 1 431 Journal of Atherosclerosis and Thrombosis Vol・17, No・5 Review …

Loss of vascular smooth muscle cell (VSMC) function is a hallmark of vascular disease.
VSMCs become increasingly dysregulated, apoptotic, and senescent as we age. Sirtuin 1 …

Aim: Silencing information regulator (SirT1), a NAD-dependent histone deacetylase, is an
essential mediator of longevity in normal cells by calorie restriction. SirT1 has many …