Cardiovascular disease is the leading cause of death worldwide. As such, there is great
interest in identifying novel mechanisms that govern the cardiovascular response to disease …

Autophagy is an evolutionarily ancient process of intracellular catabolism necessary to
preserve cellular homeostasis in response to a wide variety of stresses. In the case of post …

Autophagy is a major cytoprotective pathway that eukaryotic cells use to degrade and
recycle cytoplasmic contents. Recent evidence indicates that autophagy under baseline …

Autophagy is an evolutionarily conserved process by which long-lived proteins and
organelles are sequestered by autophagosomes and subsequently degraded by lysosomes …

Autophagy is a catabolic recycling pathway triggered by various intra-or extracellular stimuli
that is conserved from yeast to mammals. During autophagy, diverse cytosolic constituents …

Despite recent scientific and technological advances, cardiovascular disease remains the
leading cause of morbidity and mortality worldwide. Autophagy, an evolutionarily ancient …

The epidemic of heart failure continues apace, and development of novel therapies with
clinical efficacy has lagged. Now, important insights into the molecular circuitry of …

Autophagy is a highly conserved mechanism of lysosome-mediated protein and organelle
degradation that plays a crucial role in maintaining cellular homeostasis. In the last few …

Autophagy is a cellular housekeeping and quality control mechanism that is essential for
homeostasis and survival. By virtue of this role, any perturbations to the flow of this process …

The study of autophagy has been transformed by the cloning of most genes in the pathway
and the introduction of GFP-LC3 as a reporter to allow visual assessment of autophagy. The …