Protecting the BBB endothelium against cigarette smoke-induced oxidative stress using popular antioxidants: Are they really beneficial?
Abstract Blood Brain Barrier (BBB) exposed to realistic concentrations (comparable to a
chronic heavy smoker) of Cigarette Smoke Extract (CSE) triggers a strong endothelial …
chronic heavy smoker) of Cigarette Smoke Extract (CSE) triggers a strong endothelial …
[HTML][HTML] Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free …
Background Both active and passive tobacco smoke (TS) potentially impair the vascular
endothelial function in a causative and dose-dependent manner, largely related to the …
endothelial function in a causative and dose-dependent manner, largely related to the …
[HTML][HTML] Effect of full flavor and denicotinized cigarettes exposure on the brain microvascular endothelium: a microarray-based gene expression study using a human …
Background Tobacco smoke (TS) toxicity to the brain microvasculature is still an
understudied area till date. NF-E2 related factor (Nrf2) is a key transcription factor …
understudied area till date. NF-E2 related factor (Nrf2) is a key transcription factor …
[HTML][HTML] In vitro assessment of tobacco smoke toxicity at the BBB: do antioxidant supplements have a protective role?
Background Tobacco smoke (TS) contains highly reactive oxygen species (such as
hydrogen peroxide, peroxynitrite, etc), which cause oxidative damage in vascular tissue and …
hydrogen peroxide, peroxynitrite, etc), which cause oxidative damage in vascular tissue and …
[HTML][HTML] Cigarette smoke extract exacerbates hyperpermeability of cerebral endothelial cells after oxygen glucose deprivation and reoxygenation
Cigarette smoking is a risk factor for stroke and is linked to stroke severity. Previous studies
have shown that cigarette smoke extract (CSE) triggers endothelial dysfunction in vitro by …
have shown that cigarette smoke extract (CSE) triggers endothelial dysfunction in vitro by …
Tobacco smoke: A critical etiological factor for vascular impairment at the blood–brain barrier
M Hossain, T Sathe, V Fazio, P Mazzone, B Weksler… - Brain research, 2009 - Elsevier
Active and passive tobacco smoke are associated with the dysfunction of endothelial
physiology and vascular impairment. Studies correlating the effects of smoking and the brain …
physiology and vascular impairment. Studies correlating the effects of smoking and the brain …
[HTML][HTML] Impact of cigarette smoke extract and hyperglycemic conditions on blood–brain barrier endothelial cells
Background Diabetes and tobacco smoking are significant public health concerns which
have been shown to independently impact the blood–brain barrier (BBB). Since smoking is …
have been shown to independently impact the blood–brain barrier (BBB). Since smoking is …
[HTML][HTML] Offsetting the impact of smoking and e-cigarette vaping on the cerebrovascular system and stroke injury: Is Metformin a viable countermeasure?
Recently published in vitro and in vivo findings strongly suggest that BBB impairment and
increased risk for stroke by tobacco smoke (TS) closely resemble that of type-2 diabetes …
increased risk for stroke by tobacco smoke (TS) closely resemble that of type-2 diabetes …
Stabilization of superoxide dismutase by acetyl-l-carnitine in human brain endothelium during alcohol exposure: novel protective approach
J Haorah, NA Floreani, B Knipe, Y Persidsky - Free Radical Biology and …, 2011 - Elsevier
Oxidative damage of the endothelium disrupts the integrity of the blood–brain barrier (BBB).
We have shown before that alcohol exposure increases the levels of reactive oxygen …
We have shown before that alcohol exposure increases the levels of reactive oxygen …
Oxidative stress induced by cigarette smoke extracts in human brain cells (T98G) and human brain microvascular endothelial cells (HBMEC) in mono-and co-culture
The objective of the current study was to examine oxidative stress induced by cigarette
smoke extract (CSE) or cigarette smoke condensate (CSC) in human brain cells (T98G) and …
smoke extract (CSE) or cigarette smoke condensate (CSC) in human brain cells (T98G) and …