Obesity has become a great problem worldwide. According to world health organization
reports in 2016, more than 1.9 billion adults were overweight worldwide and over 650 …

Emerging evidence has suggested a possible physiologic role for peripheral glucagon-like
peptide 1 (GLP-1) in regulating glucose metabolism and food intake. The likely site of action …

For humans, eating control is crucial. When metabolic homeostasis can be maintained,
feeding function involves the hypothalamus and brain stem. When food intake exceeds …

Background: Feeding is a complex survival behavior mediated by multiple signaling
pathways and stop-and-go neural circuits in the central nervous system. Understanding the …

Obesity is a critical health condition worldwide that increases the risks of comorbid chronic
diseases, but it can be managed with weight loss. However, conventional interventions …

Glucagon-like peptide-1 (GLP-1), produced in the intestine and the brain, regulates food
intake and glucose metabolism. A GLP-1 based treatment is already approved for clinical …

The glucagon-like peptide 1 (GLP-1) system has emerged as an important drug target for the
treatment of obesity and diabetes. Preclinical and clinical studies demonstrate that the …

Stress and low mood are powerful triggers for compulsive overeating, a maladaptive form of
eating leading to negative physical and mental health consequences. Stress-vulnerable …

Dysfunction of the gut-brain axis is one of the potential contributors to the pathophysiology of
obesity and is therefore a potential target for treatment. Vagal afferents innervating the gut …