[HTML][HTML] Nesprin‑1 has key roles in the process of mesenchymal stem cell differentiation into cardiomyocyte‑like cells in vivo and in vitro

W Yang, H Zheng, Y Wang… - Molecular medicine …, 2015 - spandidos-publications.com
The aim of the present study was to investigate the expression of nesprin‑1 protein in MSCs
and its effects on the differentiation of rat bone‑marrow mesenchymal stem cells (MSCs) …

[HTML][HTML] Nesprin-1 plays an important role in the proliferation and apoptosis of mesenchymal stem cells

W Yang, H Zheng, Y Wang… - International …, 2013 - spandidos-publications.com
The aim of this study was to investigate the expression of nesprin‑1 protein and its effects on
rat bone marrow mesenchymal stem cells (MSCs). MSCs were cultured in DMEM and …

Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis

C Zhou, C Li, B Zhou, H Sun… - Human molecular …, 2017 - academic.oup.com
Abstract Nesprins-1 and-2 are highly expressed in skeletal and cardiac muscle and together
with SUN (Sad1p/UNC84)-domain containing proteins and lamin A/C form the LInker of …

Up‐regulation of nestin in the infarcted myocardium potentially indicates differentiation of resident cardiac stem cells into various lineages including cardiomyocytes

S Scobioala, R Klocke, M Kuhlmann, W Tian… - The FASEB …, 2008 - Wiley Online Library
To identify proteins involved in cardiac regeneration, a proteomics approach was applied. A
total of 26 proteins, which displayed aberrant expression in mouse hearts infarcted through …

Depletion of Nesprin-2 is associated with an embryonic lethal phenotype in mice

C Mroß, M Marko, M Munck, G Glöckner, S Motameny… - Nucleus, 2018 - Taylor & Francis
Nesprin-2 is a nuclear envelope component and provides a link between cytoskeletal
components of the cytoplasm and the nucleoplasm. Several isoforms are generated from its …

Nesprin‐1 and nesprin‐2 regulate endothelial cell shape and migration

SJ King, K Nowak, N Suryavanshi, I Holt… - …, 2014 - Wiley Online Library
Nesprins are large multi‐domain proteins that link the nuclear envelope to the cytoskeleton
and nucleoskeleton. Here we show that nesprin‐1 and nesprin‐2 play important roles in …

[HTML][HTML] Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds

D Rajgor, JA Mellad, F Autore, Q Zhang… - PloS one, 2012 - journals.plos.org
Background Nesprins (N uclear e nvelope s pectrin-r epeat p roteins) are a novel family of
giant spectrin-repeat containing proteins. The nesprin-1 and nesprin-2 genes consist of 146 …

Nesprin-1 mutations in human and murine cardiomyopathy

MJ Puckelwartz, EJ Kessler, G Kim, MM DeWitt… - Journal of molecular and …, 2010 - Elsevier
Mutations in LMNA, the gene encoding the nuclear membrane proteins, lamins A and C,
produce cardiac and muscle disease. In the heart, these autosomal dominant LMNA …

[HTML][HTML] Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the …

I Banerjee, J Zhang, T Moore-Morris, E Pfeiffer… - PLoS …, 2014 - journals.plos.org
Recent interest has focused on the importance of the nucleus and associated
nucleoskeleton in regulating changes in cardiac gene expression in response to …

Human mesenchymal stem cells differentiate into neuron-like cells and show SMN protein expression

XS Yang, HX Wu, B Xiao - Zhonghua yi xue za zhi, 2005 - europepmc.org
Objectives To investigate the mRNA and protein expression of SMN gene in neuron-like
cells by inducing MSC to differentiate into neuron-like cells. Methods Human MSC (hMSC) …