Anaplastic thyroid cancer (ATC) is one of the most aggressive human cancers. Key signal
transduction pathways that regulate mitochondrial metabolism are frequently altered in ATC …

Metabolic dysregulation within the tumor microenvironment (TME) is critical to the process of
tumorigenesis in various cancer types. Thyrocyte metabolism in papillary and anaplastic …

Background Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused
by mutations in the rearranged during transfection (RET) proto-oncogene. Not all patients …

Context: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by
mutations in the RET proto-oncogene. For MTC therapy, the US Food and Drug …

Objectives/Hypothesis In many cancers, varying regions within the tumor are often
phenotypically heterogeneous, including their metabolic phenotype. Further, tumor regions …

Mitotane is used for the treatment of adrenocortical cancer and elicits its anticancer effects
via inhibition of mitochondrial respiration. Targeting mitochondria‑dependent metabolism …

Monocarboxylate transporters (MCT) modulate tumor cell metabolism and offer promising
therapeutic targets for cancer treatment. Understanding the impact of MCT blockade on …

Thyroid cancer (TC) is the most common type of endocrine malignancy. Tumour formation,
progression, and metastasis greatly depend on the efficacy of mitochondria—primarily, the …

We conducted the first systematic omics study of the oncocytic phenotype in 488 papillary
thyroid carcinomas (PTC) from The Cancer Genome Atlas. Oncocytic phenotype is …

Thyroid oncocytoma is characterized by the presence of oncocytes containing abnormally
large numbers of mitochondria. However, the relationship between the abundance of …