Over 50% of HIV-1/AIDS patients suffer chronic pain. Currently, opioids are the cornerstone
medications for treating severe pain in these patients. Ironically, emerging clinical data …

Background One of the most discomfortable dose-limiting adverse reactions of effective
drugs for the treatment of solid tumors is a peripheral neuropathy which is the main reason …

Objective This study investigated post-surgical changes in pain among endometrial cancer
patients, as well as the extent to which emotional distress and inflammatory and regulatory …

Background Previous studies have demonstrated that glial cells play an important role in the
generation and maintenance of neuropathic pain. Activated glial cells produce numerous …

Pain is a distressing sensation, resulting from real or potential tissue damage. It is crucial to
protect our body, but it can be so intense that it requires treatment. Furthermore, in some …

Stress has been shown to enhance pain sensitivity resulting in stress-induced hyperalgesia.
However, the underlying mechanisms have yet to be elucidated. Using single-prolonged …

Visceral hypersensitivity is a common characteristic in patients suffering from irritable bowel
syndrome (IBS) and other disorders with visceral pain. Although the pathogenesis of visceral …

Segmentation and analysis of histological images provides a valuable tool to gain insight
into the biology and function of microglial cells in health and disease. Common image …

Background Chronic migraine (CM) is problematic, and there are few effective treatments.
Recently, it has been hypothesized that glial activation may be a contributor to migraine; …

Whole‐body vibration (WBV) is linked epidemiologically to neck and back pain in humans,
and to forepaw mechanical allodynia and cervical neuroinflammation in a rodent model of …