[HTML][HTML] Fast and rigorous computation of gene and pathway scores from SNP-based summary statistics
Integrating single nucleotide polymorphism (SNP) p-values from genome-wide association
studies (GWAS) across genes and pathways is a strategy to improve statistical power and …
studies (GWAS) across genes and pathways is a strategy to improve statistical power and …
Cardiometabolic risk loci share downstream cis-and trans-gene regulation across tissues and diseases
Genome-wide association studies (GWAS) have identified hundreds of cardiometabolic
disease (CMD) risk loci. However, they contribute little to genetic variance, and most …
disease (CMD) risk loci. However, they contribute little to genetic variance, and most …
[HTML][HTML] Genetic evidence for causal relationships between maternal obesity-related traits and birth weight
Importance Neonates born to overweight or obese women are larger and at higher risk of
birth complications. Many maternal obesity-related traits are observationally associated with …
birth complications. Many maternal obesity-related traits are observationally associated with …
[HTML][HTML] Recent progress in genetic and epigenetic research on type 2 diabetes
Abstract Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong
genetic predisposition. During the past decade, progress in genetic association studies has …
genetic predisposition. During the past decade, progress in genetic association studies has …
Desaturase and elongase-limiting endogenous long-chain polyunsaturated fatty acid biosynthesis
JY Zhang, KSD Kothapalli… - Current Opinion in Clinical …, 2016 - journals.lww.com
Desaturase and elongase-limiting endogenous long-chain polyu... : Current Opinion in Clinical
Nutrition & Metabolic Care Desaturase and elongase-limiting endogenous long-chain …
Nutrition & Metabolic Care Desaturase and elongase-limiting endogenous long-chain …
The importance of gene–environment interactions in human obesity
The worldwide obesity epidemic has been mainly attributed to lifestyle changes. However,
who becomes obese in an obesity-prone environment is largely determined by genetic …
who becomes obese in an obesity-prone environment is largely determined by genetic …
[HTML][HTML] Molecular genetic contributions to social deprivation and household income in UK Biobank
Individuals with lower socio-economic status (SES) are at increased risk of physical and
mental illnesses and tend to die at an earlier age [1–3]. Explanations for the association …
mental illnesses and tend to die at an earlier age [1–3]. Explanations for the association …
Type 2 diabetes: genetic data sharing to advance complex disease research
J Flannick, JC Florez - Nature Reviews Genetics, 2016 - nature.com
As with other complex diseases, unbiased association studies followed by physiological and
experimental characterization have for years formed a paradigm for identifying genes or …
experimental characterization have for years formed a paradigm for identifying genes or …
[HTML][HTML] Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes
M Imamura, A Takahashi, T Yamauchi, K Hara… - Nature …, 2016 - nature.com
Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci
for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this …
for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this …
Causal assessment of serum urate levels in cardiometabolic diseases through a Mendelian randomization study
Background: Although epidemiological studies have reported positive associations between
circulating urate levels and cardiometabolic diseases, causality remains uncertain …
circulating urate levels and cardiometabolic diseases, causality remains uncertain …