To date, more than 30 genes have been linked to monogenic diabetes. Candidate gene and
genome-wide association studies have identified> 50 susceptibility loci for common type 1 …

Background: Epidemiological studies show that high circulating cystatin C is associated with
risk of cardiovascular disease (CVD), independent of creatinine-based renal function …

Circadian clocks are cell-autonomous timing mechanisms that organize cell functions in a
24-h periodicity. In mammals, the main circadian oscillator consists of transcription …

Elevated concentrations of albumin in the urine, albuminuria, are a hallmark of diabetic
kidney disease and are associated with an increased risk for end-stage renal disease and …

Objective Gout, caused by hyperuricaemia, is a multifactorial disease. Although genome-
wide association studies (GWASs) of gout have been reported, they included self-reported …

Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We
conducted a genome-wide association study (GWAS) followed by replication in a combined …

Familial Advanced Sleep Phase (FASP) is a heritable human sleep phenotype
characterized by very early sleep and wake times. We identified a missense mutation in the …

Gestational diabetes mellitus (GDM) is defined as abnormal glucose tolerance with onset or
first recognition during pregnancy. Women with a history of GDM are at long-term risk for …

Many aspects of human health and disease display daily rhythmicity. The brain's
suprachiasmic nucleus, which interprets recurring external stimuli, and autonomous …

The circadian clock directs nearly all aspects of diurnal physiology, including metabolism.
Current research identifies several major axes by which it exerts these effects, including …