The growth hormone/insulin‐like growth factor (IGF) axis can be manipulated in animal
models to promote longevity, and IGF‐related proteins including IGF‐I and IGF‐binding …

Aims/hypothesis Low birthweight has been associated with a high risk of type 2 diabetes
mellitus in observational studies. However, it remains unclear whether this relation is causal …

Context: The metabolic syndrome (MetS) is associated with type 2 diabetes (T2D). However,
whether each of the 5 components of the MetS individually is causally associated with T2D …

The proposed bidirectional relationship between acute pancreatitis (AP) and diabetes has
never been examined with the same source of data. Furthermore, the effects of disease …

Observationally, coffee is inversely associated with type 2 diabetes mellitus (T2DM),
depression and Alzheimer's disease, but not ischemic heart disease (IHD). Coffee features …

Purpose To examine the longitudinal associations of serum fatty acid composition with type
2 diabetes, insulin secretion and insulin sensitivity over several years. Methods We …

Mendelian randomization (MR) is a technique that seeks to establish causation between an
exposure and an outcome using observational data. It is an instrumental variable analysis in …

Abstract The Framingham Heart Study (FHS), initiated in 1948, is the longest running
prospective cohort study in the USA. Through> 65 years of discovery, the FHS has …

A series of novel carbazole-containing sulfonamides and sulfamides were synthesized. A
structure–activity relationship study of these compounds led to the identification of potent …

Knowledge of the genetic basis of the type 2 diabetes (T2D)-related quantitative traits fasting
glucose (FG) and insulin (FI) in African ancestry (AA) individuals has been limited. In non …